GSK878 is a long-lasting HIV-1 capsid inhibitor for use against HIV-1. GSK878 is highly potent, inhibiting an HIV-1 reporter virus in MT-2 cells with a mean 50% effective concentration (EC50) of 39 pM and inhibiting a panel of 48 chimeric viruses containing diverse CA sequences with a mean EC50 of 94 pM. GSK878 blocked both early (preintegration) and late (postintegration) steps in HIV-1 replication, with the early inhibition primarily determining the compound's antiviral activity.
MedKoo Cat#: 130288
Name: GSK878
CAS#: 2417048-11-2
Chemical Formula: C41H38ClF6N9O5S
Exact Mass: 917.2309
Molecular Weight: 918.31
Elemental Analysis: C, 53.63; H, 4.17; Cl, 3.86; F, 12.41; N, 13.73; O, 8.71; S, 3.49
The following data is based on the product molecular weight 918.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
