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MedKoo Cat#: 329630 | Name: Trolamine salicylate ester

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trolamine salicylate (ester) is a salicylate ester with Trolamine. Trolamine salicylate ester may have better skin penetration as compared to Trolamine salicylate salt. The penetration of active ingredients from topically applied anti-inflammatory pharmaceutical products into tissues below the skin is the basis of their therapeutic efficacy.

Chemical Structure

Trolamine salicylate ester
Trolamine salicylate ester
CAS#10377-95-4 (ester)

Theoretical Analysis

MedKoo Cat#: 329630

Name: Trolamine salicylate ester

CAS#: 10377-95-4 (ester)

Chemical Formula: C13H19NO5

Exact Mass: 269.1263

Molecular Weight: 269.30

Elemental Analysis: C, 57.98; H, 7.11; N, 5.20; O, 29.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
10377-95-4 (ester) 2174-16-5 (salt)
Synonym
Trolamine salicylate (ester);
IUPAC/Chemical Name
2-(Bis(2-hydroxyethyl)amino)ethyl salicylate
InChi Key
NAFDCRMGWKHMJQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H19NO5/c15-8-5-14(6-9-16)7-10-19-13(18)11-3-1-2-4-12(11)17/h1-4,15-17H,5-10H2
SMILES Code
OC1=CC=CC=C1C(OCCN(CCO)CCO)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 269.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sajjadi P, Khodayar MJ, Sharif Makhmalzadeh B, Rezaee S. Percutaneous absorption of salicylic Acid after administration of trolamine salicylate cream in rats with transcutol(®) and eucalyptus oil pre-treated skin. Adv Pharm Bull. 2013;3(2):295-301. doi: 10.5681/apb.2013.048. Epub 2013 Aug 20. PubMed PMID: 24312851; PubMed Central PMCID: PMC3848229. 2: Baldwin JR, Carrano RA, Imondi AR. Penetration of trolamine salicylate into the skeletal muscle of the pig. J Pharm Sci. 1984 Jul;73(7):1002-4. PubMed PMID: 6470939. 3: Algozzine GJ, Stein GH, Doering PL, Araujo OE, Akin KC. Trolamine salicylate cream in osteoarthritis of the knee. JAMA. 1982 Mar 5;247(9):1311-3. PubMed PMID: 7038182. 4: Ciccone CD, Leggin BG, Callamaro JJ. Effects of ultrasound and trolamine salicylate phonophoresis on delayed-onset muscle soreness. Phys Ther. 1991 Sep;71(9):666-75; discussion 675-8. PubMed PMID: 1881957. 5: Trolamine salicylate cream in osteoarthritis. JAMA. 1982 Oct 1;248(13):1577-8. PubMed PMID: 7050447. 6: Hill DW, Richardson JD. Effectiveness of 10% trolamine salicylate cream on muscular soreness induced by a reproducible program of weight training. J Orthop Sports Phys Ther. 1989;11(1):19-23. PubMed PMID: 18796932. 7: Rothacker DQ, Lee I, Littlejohn TW 3rd. Effectiveness of a single topical application of 10|x% trolamine salicylate cream in the symptomatic treatment of osteoarthritis. J Clin Rheumatol. 1998 Feb;4(1):6-12. PubMed PMID: 19078236. 8: Morra P, Bartle WR, Walker SE, Lee SN, Bowles SK, Reeves RA. Serum concentrations of salicylic acid following topically applied salicylate derivatives. Ann Pharmacother. 1996 Sep;30(9):935-40. PubMed PMID: 8876850. 9: Hoffman RJ, Nelson LS, Hoffman RS. Use of ferric chloride to identify salicylate-containing poisons. J Toxicol Clin Toxicol. 2002;40(5):547-9. PubMed PMID: 12215048. 10: Oziomek RS, Perrin DH, Herold DA, Denegar CR. Effect of phonophoresis on serum salicylate levels. Med Sci Sports Exerc. 1991 Apr;23(4):397-401. PubMed PMID: 2056895. 11: Rabinowitz JL, Feldman ES, Weinberger A, Schumacher HR. Comparative tissue absorption of oral 14C-aspirin and topical triethanolamine 14C-salicylate in human and canine knee joints. J Clin Pharmacol. 1982 Jan;22(1):42-8. PubMed PMID: 6977559. 12: Davis RE, Wachholz JH, Jassir D, Perlyn CA, Agrama MH. Comparison of topical anti-ischemic agents in the salvage of failing random-pattern skin flaps in rats. Arch Facial Plast Surg. 1999 Jan-Mar;1(1):27-32. PubMed PMID: 10937072. 13: Ragan BG, Nelson AJ, Bell GW, Iwamoto GA. Salicylate-based analgesic balm attenuates pressor responses from skeletal muscle. Med Sci Sports Exerc. 2007 Nov;39(11):1942-8. PubMed PMID: 17986901. 14: Rabinowitz JL, Baker D. Absorption of labeled triethanolamine salicylate in human and canine knee joints. II. J Clin Pharmacol. 1984 Nov-Dec;24(11-12):532-9. PubMed PMID: 6334699. 15: Cross SE, Anderson C, Roberts MS. Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies. Br J Clin Pharmacol. 1998 Jul;46(1):29-35. PubMed PMID: 9690946; PubMed Central PMCID: PMC1873984. 16: Babar A, Chickhale PJ, Plakogiannis FM. Assessment of triethanolamine salicylate release from the dermatological bases and the commercial products. Pharm Acta Helv. 1991;66(12):322-8. PubMed PMID: 1784579. 17: HEISEY HO. INFRARED ABSORPTION RATIO METHOD FOR DETERMINATION OF TRIETHANOLAMINE SALICYLATE IN OINTMENT. J Pharm Sci. 1964 Dec;53:1553-4. PubMed PMID: 14255150. 18: Cross SE, Megwa SA, Benson HA, Roberts MS. Self promotion of deep tissue penetration and distribution of methylsalicylate after topical application. Pharm Res. 1999 Mar;16(3):427-33. PubMed PMID: 10213375. 19: Chargari C, Fromantin I, Kirova YM. [Importance of local skin treatments during radiotherapy for prevention and treatment of radio-induced epithelitis]. Cancer Radiother. 2009 Jul;13(4):259-66. doi: 10.1016/j.canrad.2009.04.003. Epub 2009 Jun 12. Review. French. PubMed PMID: 19524470.