GSK6776 | BRD7/9 inhibitor

MedKoo Cat#: 462224 | Name: GSK6776

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK6776 is a soluble, permeable, and selective BRD7/9 inhibitor.

Chemical Structure

GSK6776

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 462224

Name: GSK6776

CAS#: unknown

Chemical Formula: C21H31N5O

Exact Mass: 369.2529

Molecular Weight: 369.51

Elemental Analysis: C, 68.26; H, 8.46; N, 18.95; O, 4.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GSK-6776; GSK6776; GSK 6776

IUPAC/Chemical Name

4-butyl-2-methyl-5-((2-(4-methylpiperazin-1-yl)benzyl)amino)pyridazin-3(2H)-one

InChi Key

UXFKGTAATGRBOW-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H31N5O/c1-4-5-9-18-19(16-23-25(3)21(18)27)22-15-17-8-6-7-10-20(17)26-13-11-24(2)12-14-26/h6-8,10,16,22H,4-5,9,11-15H2,1-3H3

SMILES Code

O=C1C(CCCC)=C(NCC2=CC=CC=C2N3CCN(C)CC3)C=NN1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 369.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Clegg MA, Bamborough P, Chung CW, et al. Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. J Med Chem. 2020;63(11):5816-5840. doi:10.1021/acs.jmedchem.0c0007