EPZ-719 is a novel and potent SETD2 inhibitor ( IC50 = 0.005 μM) with a high selectivity over other histone methyltransferases. SET domain-containing protein 2 (SETD2), a histone methyltransferase, has been identified as a target of interest in certain hematological malignancies, including multiple myeloma.
MedKoo Cat#: 408194
Name: EPZ-719 free base
CAS#: 2697176-16-0 (free base)
Chemical Formula: C22H31FN4O3S
Exact Mass: 450.2101
Molecular Weight: 450.57
Elemental Analysis: C, 58.65; H, 6.94; F, 4.22; N, 12.43; O, 10.65; S, 7.12
The following data is based on the product molecular weight 450.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
