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MedKoo Cat#: 462269 | Name: Sulfo-SIAB
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfo-SIAB is a crosslinker for amine-to-sulfhydryl conjugation via sulfo-N-hydroxysuccinimide (sulfo-NHS) ester and iodoacetyl reactive groups.

Chemical Structure

Sulfo-SIAB
Sulfo-SIAB
CAS#106145-13-5

Theoretical Analysis

MedKoo Cat#: 462269

Name: Sulfo-SIAB

CAS#: 106145-13-5

Chemical Formula: C13H11IN2O8S

Exact Mass: 481.9280

Molecular Weight: 482.20

Elemental Analysis: C, 32.38; H, 2.30; I, 26.32; N, 5.81; O, 26.54; S, 6.65

Price and Availability

Size Price Availability Quantity
50mg USD 500.00 2 Weeks
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Related CAS #
No Data
Synonym
Sulfo-SIAB; Sulfo SIAB
IUPAC/Chemical Name
1-((4-(2-iodoacetamido)benzoyl)oxy)-2,5-dioxopyrrolidine-3-sulfonic acid
InChi Key
CULQNACJHGHAER-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H11IN2O8S/c14-6-10(17)15-8-3-1-7(2-4-8)13(20)24-16-11(18)5-9(12(16)19)25(21,22)23/h1-4,9H,5-6H2,(H,15,17)(H,21,22,23)
SMILES Code
O=C(ON1C(C(S(=O)(O)=O)CC1=O)=O)C2=CC=C(NC(CI)=O)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 482.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Resto M, Vinitsky A, Schneck NA, Wolff JJ, Shajahan A, Cibelli N, Zhang Y, Li Y, Gulla K, Gowetski DB, Gall JG, Lei QP. Determination of degradation for sulfo-SIAB, SM(PEG)2, and sulfo-GMBS by RPLC-UV analysis. J Pharm Biomed Anal. 2024 Dec 15;251:116455. doi: 10.1016/j.jpba.2024.116455. Epub 2024 Aug 30. PMID: 39232447. 2: Ou L, Kong WP, Chuang GY, Ghosh M, Gulla K, O'Dell S, Varriale J, Barefoot N, Changela A, Chao CW, Cheng C, Druz A, Kong R, McKee K, Rawi R, Sarfo EK, Schön A, Shaddeau A, Tsybovsky Y, Verardi R, Wang S, Wanninger TG, Xu K, Yang GJ, Zhang B, Zhang Y, Zhou T; VRC Production Program; Arnold FJ, Doria-Rose NA, Lei QP, Ryan ET, Vann WF, Mascola JR, Kwong PD. Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen. Sci Rep. 2020 Feb 20;10(1):3032. doi: 10.1038/s41598-020-59711-y. PMID: 32080235; PMCID: PMC7033230. 3: Patrulea V, Hirt-Burri N, Jeannerat A, Applegate LA, Ostafe V, Jordan O, Borchard G. Peptide-decorated chitosan derivatives enhance fibroblast adhesion and proliferation in wound healing. Carbohydr Polym. 2016 May 20;142:114-23. doi: 10.1016/j.carbpol.2016.01.045. Epub 2016 Jan 22. PMID: 26917381. 4: Qian F. [Conjugation of Plasmodium falciparum Pfs25 to Pseudomonas aeruginosa ExoProtein A with different chemical linkers]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2011 Aug;29(4):254-7. Chinese. PMID: 21972597. 5: Gubala V, Le Guevel X, Nooney R, Williams DE, MacCraith B. A comparison of mono and multivalent linkers and their effect on the colloidal stability of nanoparticle and immunoassays performance. Talanta. 2010 Jun 15;81(4-5):1833-9. doi: 10.1016/j.talanta.2010.03.048. Epub 2010 Mar 31. PMID: 20441982. 6: Hess R, Rau P, Schwab M, Paetzold S, Kuther M, Obert M, Agostini H, Haessler C, Braun DG, Brandner G. Covalent immunochemical membrane labeling of viable cells with K698-T708, a simian virus 40 tumor antigen-derived peptide. Pept Res. 1994 May-Jun;7(3):146-52. PMID: 7521699.

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GSK 932121

GSK 932121