MedKoo Cat#: 525182 | Name: GSK 932121

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK 932121 is a potent antimalarial agent that shows activity against Plasmodium falciparum in vitro and in vivo. GSK 932121 exerts its antimalarial action by inhibiting selectively the electron-transport chain in P. falciparum at the cytochrome bc1 level (complex III).

Chemical Structure

GSK 932121
GSK 932121
CAS#958457-44-8

Theoretical Analysis

MedKoo Cat#: 525182

Name: GSK 932121

CAS#: 958457-44-8

Chemical Formula: C20H15ClF3NO4

Exact Mass: 425.0642

Molecular Weight: 425.79

Elemental Analysis: C, 56.42; H, 3.55; Cl, 8.33; F, 13.39; N, 3.29; O, 15.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GSK 932121; GSK-932121; GSK932121;
IUPAC/Chemical Name
3-chloro-6-(hydroxymethyl)-2-methyl-5-(4-(4-(trifluoromethoxy)phenoxy)phenyl)pyridin-4(1H)-one
InChi Key
QGQFNQWZHHSZIC-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H15ClF3NO4/c1-11-18(21)19(27)17(16(10-26)25-11)12-2-4-13(5-3-12)28-14-6-8-15(9-7-14)29-20(22,23)24/h2-9,26H,10H2,1H3,(H,25,27)
SMILES Code
Cc1c(c(=O)c(c([nH]1)CO)c2ccc(cc2)Oc3ccc(cc3)OC(F)(F)F)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 425.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Capper MJ, O'Neill PM, Fisher N, Strange RW, Moss D, Ward SA, Berry NG, Lawrenson AS, Hasnain SS, Biagini GA, Antonyuk SV. Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):755-60. doi: 10.1073/pnas.1416611112. Epub 2015 Jan 6. PubMed PMID: 25564664; PubMed Central PMCID: PMC4311836. 2: Bueno JM, Herreros E, Angulo-Barturen I, Ferrer S, Fiandor JM, Gamo FJ, Gargallo-Viola D, Derimanov G. Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1. Future Med Chem. 2012 Dec;4(18):2311-23. doi: 10.4155/fmc.12.177. Review. PubMed PMID: 23234553.