AUT2 is a Kv3.1 channel modulator and serves as a potential treatment of sensory hypersensitivity in those with FXS by shifting the activation of the high-threshold current to more negative potentials. This shift, in turn, reduces the high-threshold K+ current and increases the low-threshold K+ currents in neurons, restoring wave IV of the ABR. AUT2, due to its ability to modulate the excitability of neurons, can also potentially be used as treatment for hearing disorders
MedKoo Cat#: 130162
Name: AUT2
CAS#: 1311137-58-2
Chemical Formula: C20H20N4O3
Exact Mass: 364.1535
Molecular Weight: 364.41
Elemental Analysis: C, 65.92; H, 5.53; N, 15.38; O, 13.17
The following data is based on the product molecular weight 364.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
