GUM13948| 3,3′-Dipropylthiadicarbocyanine (I) | CAS#53213-94-8 | Fluorescent dye

MedKoo Cat#: 112008 | Name: GUM13948

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

3,3′-Dipropylthiadicarbocyanine (diSC3(5)) is a fluorescent dye that has been used to monitor cell membrane potential. It displays excitation/emission maxima of 622/670 nm, respectively, and, upon cell hyperpolarization, it enters cells, and exhibits a shift in emission maxima to 688 nm and a decrease in fluorescence intensity. When the cell membrane is depolarized, the fluorescence intensity of diSC3(5) increases as it exits the cells. However, diSC3(5) (3 µM) also induces membrane hyperpolarization, increases intracellular sodium levels, and decreases intracellular potassium levels in Ehrlich ascites tumor cells, as well as increases potassium membrane permeability by 64.6% in Ehrlich ascites tumor cells in the presence of the Na+/K+-ATPase inhibitor ouabain. It also reduces cellular ATP levels in the absence of glucose and induces acid production and inhibits oxygen consumption in the presence of glucose in Ehrlich ascites tumor cells when used at a concentration of 3 µM.

Chemical Structure

GUM13948

CAS#53213-94-8

Theoretical Analysis

MedKoo Cat#: 112008

Name: GUM13948

CAS#: 53213-94-8

Chemical Formula: C25H27IN2S2

Exact Mass: 0.0000

Molecular Weight: 546.53

Elemental Analysis: C, 54.94; H, 4.98; I, 23.22; N, 5.13; S, 11.73

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 350.00	2 Weeks
250mg	USD 650.00	2 Weeks

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Related CAS #

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Synonym

DiS-C3-(5); DiSC3(5); DiSC3 (5); 3,3′-Dipropylthiadicarbocyanine iodide; 3,3′Dipropylthiadicarbocyanine (I); 3,3′ Dipropylthiadicarbocyanine (I); 3,3′-Dipropylthiadicarbocyanine (I); 3,3′ Dipropylthiadicarbocyanine I; 3,3′-Dipropylthiadicarbocyanine I; 3,3′Dipropylthiadicarbocyanine I; GUM13948; GUM 13948; GUM-13948

IUPAC/Chemical Name

3-propyl-2-((1E,3E,5E)-5-(3-propylbenzo[d]thiazol-2(3H)-ylidene)penta-1,3-dien-1-yl)benzo[d]thiazol-3-ium iodide

InChi Key

GDEURKKLNUGTDA-UHFFFAOYSA-M

InChi Code

InChI=1S/C25H27N2S2.HI/c1-3-18-26-20-12-8-10-14-22(20)28-24(26)16-6-5-7-17-25-27(19-4-2)21-13-9-11-15-23(21)29-25;/h5-17H,3-4,18-19H2,1-2H3;1H/q+1;/p-1

SMILES Code

CCCN(/C(S1)=C\C=C\C=C\C2=[N+](CCC)C(C=CC=C3)=C3S2)C4=C1C=CC=C4.[I-]

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMSO	2.0	3.66

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 546.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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