Norletimol | CAS# 886-08-8 | anti-inflammatory properties

MedKoo Cat#: 414477 | Name: Norletimol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norletimol is a Schiff base with promising anti-inflammatory properties. The time taken for elimination of 50% of the Norletimol dose in the urine was approximately five hours. As an antirheumatic agent it was tested in clinical trials in Iraq. It was used in progressive myopia in children.

Chemical Structure

Norletimol

CAS# 886-08-8

Theoretical Analysis

MedKoo Cat#: 414477

Name: Norletimol

CAS#: 886-08-8

Chemical Formula: C14H13NO

Exact Mass: 211.0997

Molecular Weight: 211.26

Elemental Analysis: C, 79.59; H, 6.20; N, 6.63; O, 7.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Norletimol; NSC128931; NSC-128931; NSC 128931

IUPAC/Chemical Name

N-(2-Hydroxybenzylidene)benzylamine

InChi Key

LPSMMAHYAIVSQW-RVDMUPIBSA-N

InChi Code

InChI=1S/C14H13NO/c16-14-9-5-4-8-13(14)11-15-10-12-6-2-1-3-7-12/h1-9,11,16H,10H2/b15-11+

SMILES Code

OC1=CC=CC=C1/C=N/CC2=CC=CC=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 211.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Al-Ani MR, Wood SG, Lawson A. The metabolism of saddamine in man: the fate of the benzylamine moiety of saddamine. Eur J Drug Metab Pharmacokinet. 1979;4(2):117-9. doi: 10.1007/BF03189411. PMID: 488132. 2: Riddle JA, Bollinger JC, Lee D. Escape from a nonporous solid: mechanically coupled biconcave molecules. Angew Chem Int Ed Engl. 2005 Oct 21;44(41):6689-93. doi: 10.1002/anie.200501888. PMID: 16173003. 3: Al-Ani MR, Wood SG, Lawson A. Comparison of the major urinary metabolites of saddamine and aspirin using thin-layer chromatography. J Chromatogr. 1978 Dec 11;166(2):626-31. doi: 10.1016/s0021-9673(00)95652-8. PMID: 748364. 4: Kirkpatrick D, Hawkins DR, Chasseaud LF, Finn CM, Conway B, Al-Ani MR, Al- Sayyab AF. The metabolism of salicylidene benzylamine, a pro-drug for salicylate, in rats and dogs. Xenobiotica. 1983 Jan;13(1):53-64. doi: 10.3109/00498258309052215. PMID: 6858201. 5: Wood SG, Al-Ani MR, Lawson A. GLC determination of purity of Schiff bases bakrine and saddamine. J Pharm Sci. 1979 Mar;68(3):374-6. doi: 10.1002/jps.2600680334. PMID: 423134. 6: Korzekwa A, Szymankiewiczowa S. Leczenie postepujacej krótkowzroczności u dzieci jonoforeza sadaminowo-wapniowa i difrarelem [Treatment of progressive myopia in children by saddamine and calcium iontophoresis and difrarel]. Klin Oczna. 1985 Aug;87(8):322-3. Polish. PMID: 3831573.