DN-2 is a DCN1-UBC12 inhibitor. DN-2 specifically targeted DCN1 at molecular and cellular levels as shown by molecular modeling studies, HTRF, cellular thermal shift and co-immunoprecipitation assays. Importantly, DN-2 effectively reversed Ang II-induced cardiac fibroblast activation, which was associated with the inhibition of cullin 3 neddylation. Our findings indicate a potentially unrecognized role of DCN1 inhibition for anticardiac fibrotic effects.
MedKoo Cat#: 465734
Name: DN-2
CAS#: unknown
Chemical Formula: C23H20ClN7O3S2
Exact Mass: 541.0758
Molecular Weight: 542.03
Elemental Analysis: C, 50.97; H, 3.72; Cl, 6.54; N, 18.09; O, 8.86; S, 11.83
The following data is based on the product molecular weight 542.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
