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MedKoo Cat#: 122421 | Name: LM22A-4
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LM22A-4 is TrkB receptor agonist and is a candidate for treatment of Huntington’s disease.

Chemical Structure

LM22A-4
LM22A-4
CAS#37988-18-4

Theoretical Analysis

MedKoo Cat#: 122421

Name: LM22A-4

CAS#: 37988-18-4

Chemical Formula: C15H21N3O6

Exact Mass: 339.1430

Molecular Weight: 339.35

Elemental Analysis: C, 53.09; H, 6.24; N, 12.38; O, 28.29

Price and Availability

Size Price Availability Quantity
10mg USD 300.00 2 Weeks
25mg USD 585.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
LM22A-4; LM22A4; LM 22A4
IUPAC/Chemical Name
N1,N3,N5-tris(2-hydroxyethyl)benzene-1,3,5-tricarboxamide
InChi Key
RGWJKANXFYJKHN-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)
SMILES Code
OCCNC(C1=CC(C(NCCO)=O)=CC(C(NCCO)=O)=C1)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 339.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ding Y, Chow SH, Chen J, Brun APL, Wu CM, Duff AP, Wang Y, Song J, Wang JH, Wong VHY, Zhao D, Nishimura T, Lee TH, Conn CE, Hsu HY, Bui BV, Liu GS, Shen HH. Targeted delivery of LM22A-4 by cubosomes protects retinal ganglion cells in an experimental glaucoma model. Acta Biomater. 2021 May;126:433-444. doi: 10.1016/j.actbio.2021.03.043. Epub 2021 Mar 24. PMID: 33774200. 2: Fletcher JL, Dill LK, Wood RJ, Wang S, Robertson K, Murray SS, Zamani A, Semple BD. Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury. Exp Neurol. 2021 May;339:113652. doi: 10.1016/j.expneurol.2021.113652. Epub 2021 Feb 18. Erratum in: Exp Neurol. 2021 Sep;343:113790. PMID: 33609501. 3: Nguyen HTH, Wood RJ, Prawdiuk AR, Furness SGB, Xiao J, Murray SS, Fletcher JL. TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum. Front Mol Neurosci. 2019 Aug 27;12:205. doi: 10.3389/fnmol.2019.00205. PMID: 31507374; PMCID: PMC6718610. 4: Yu G, Wang W. Protective effects of LM22A-4 on injured spinal cord nerves. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6526-32. PMID: 26261531; PMCID: PMC4525865. 5: Kajiya M, Takeshita K, Kittaka M, Matsuda S, Ouhara K, Takeda K, Takata T, Kitagawa M, Fujita T, Shiba H, Kurihara H. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade. Int Immunopharmacol. 2014 Apr;19(2):245-52. doi: 10.1016/j.intimp.2014.01.028. Epub 2014 Feb 11. PMID: 24530412. 6: Fletcher JL, Dill LK, Wood RJ, Wang S, Robertson K, Murray SS, Zamani A, Semple BD. Corrigendum to "Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury" [Experimental Neurology 339 (2021): 113652]. Exp Neurol. 2021 Sep;343:113790. doi: 10.1016/j.expneurol.2021.113790. Epub 2021 Jun 26. Erratum for: Exp Neurol. 2021 May;339:113652. PMID: 34187696.