MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 597729 | Name: Glycine-pentagastrin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glycine-pentagastrin enhances gastric mucosal defence mechanisms against acid and protects the gastric mucosa from experimental injury.

Chemical Structure

Glycine-pentagastrin
Glycine-pentagastrin
CAS#5915-71-9

Theoretical Analysis

MedKoo Cat#: 597729

Name: Glycine-pentagastrin

CAS#: 5915-71-9

Chemical Formula: C36H47N7O9S

Exact Mass: 753.3156

Molecular Weight: 753.87

Elemental Analysis: C, 57.36; H, 6.28; N, 13.01; O, 19.10; S, 4.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Glycine-pentagastrin; Glycine pentagastrin; Glycinepentagastrin; Boc-gly-trp-met-asp-phe-NH2; Tbgtmap;
IUPAC/Chemical Name
(9S,12S,15S)-9-((1H-indol-3-yl)methyl)-15-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-2,2-dimethyl-12-(2-(methylthio)ethyl)-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazaheptadecan-17-oic acid
InChi Key
BREYNZGSJQHWMM-LJWNLINESA-N
InChi Code
InChI=1S/C36H47N7O9S/c1-36(2,3)52-35(51)39-20-29(44)40-27(17-22-19-38-24-13-9-8-12-23(22)24)33(49)41-25(14-15-53-4)32(48)43-28(18-30(45)46)34(50)42-26(31(37)47)16-21-10-6-5-7-11-21/h5-13,19,25-28,38H,14-18,20H2,1-4H3,(H2,37,47)(H,39,51)(H,40,44)(H,41,49)(H,42,50)(H,43,48)(H,45,46)/t25-,26-,27-,28-/m0/s1
SMILES Code
O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC(OC(C)(C)C)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 753.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kato S, Okabe S, Takeuchi K. Pathways mediating pentagastrin-induced mucosal blood flow response in rat stomachs. Dig Dis Sci. 1996 Mar;41(3):485-91. PubMed PMID: 8617120. 2: Polentarutti B, Albery T, Dressman J, Abrahamsson B. Modification of gastric pH in the fasted dog. J Pharm Pharmacol. 2010 Apr;62(4):462-9. doi: 10.1211/jpp.62.04.0008. PubMed PMID: 20604835. 3: Varga L, Sasvári M, Penke B, Baláspiri O, Varró V. Metabolism of C-terminal pentapeptide of gastrin in the rat. Part IV. Catabolic pathways of the N-terminal BOC-14C-glycine fragment. Hepatogastroenterology. 1980 Apr;27(2):146-9. PubMed PMID: 7216128. 4: Chapman ML, Werther JL, Rudick J, Janowitz HD. Pentagastrin infusion-glycine instillation as a measure of acid absorption in the human stomach: comparison to an instilled acid load. Gastroenterology. 1972 Dec;63(6):962-72. PubMed PMID: 4639368. 5: Várkonyi T, Varga L, Náfrádi J, Kozma M, Kása P, Varró V. Autoradiographic study with 14C-labelled pentagastrin in the rat. Acta Hepatogastroenterol (Stuttg). 1976 Nov-Dec;23(6):426-9. PubMed PMID: 1007831. 6: Bado A, Chicau-Chovet M, Appia F, Dubrasquet M, Lecomte JM, Rozé C. Acetorphan, an enkephalinase inhibitor, decreases gastric secretion in cats. Peptides. 1987 Jan-Feb;8(1):89-93. PubMed PMID: 3554169. 7: Gjesing B. The electrolyte pattern of the gastric secretion from the vervet monkey. West Afr J Pharmacol Drug Res. 1975 Jun;2(1):10-6. PubMed PMID: 5809. 8: Chicau-Chovet M, Dubrasquet M, Chariot J, Tsocas A, Lecomte JM, Rozé C. Thiorphan and acetorphan inhibit gastric secretion by a central, non-opioid mechanism in the rat. Eur J Pharmacol. 1988 Sep 23;154(3):247-54. PubMed PMID: 3234479. 9: Kowalewski K, Zajac S, Kolodej A. Effect of release of endogenous gastrin on myoelectrical and mechanical activity of isolated canine stomach. Pharmacology. 1975;13(1):56-64. PubMed PMID: 239413. 10: Vasilevskaia LS, Laktaeva TV. [Role of the sympathetic-adrenal system in the action of parenterally administered nitrous substances on gastric secretory function]. Vopr Pitan. 1981 Jan-Feb;(1):36-9. Russian. PubMed PMID: 6784340. 11: García-Zaragozá E, Barrachina MD, Moreno L, Esplugues JV. Role of central glutamate receptors, nitric oxide and soluble guanylyl cyclase in the inhibition by endotoxin of rat gastric acid secretion. Br J Pharmacol. 2000 Jul;130(6):1283-8. PubMed PMID: 10903967; PubMed Central PMCID: PMC1572196. 12: Ormai S, Varga L, Papp M, Varró V. The distribution of 3H-gastrin and 14C-pentagastrin in the blood and lymph of rats. Acta Med Acad Sci Hung. 1976;33(1):89-93. PubMed PMID: 1023739. 13: Xiang H, Xiang GY, Lu ZM, Guo L, Eckstein H. Total enzymatic synthesis of cholecystokinin CCK-5. Amino Acids. 2004 Aug;27(1):101-5. Epub 2004 Mar 16. PubMed PMID: 15309578. 14: Schön I, Kisfaludy L, Náfrádi J, Varga L, Varró V. Pentagastrin analogs containing alpha-aminooxy acids, II. Simultaneous substitutions at the N- and C-terminus. Hoppe Seylers Z Physiol Chem. 1978 Aug;359(8):897-916. PubMed PMID: 711152. 15: Bo-Linn GW, Shanbour LL. Effects of antral ethanol on gastric acid secretion, potential difference, and serum gastrin. Proc Soc Exp Biol Med. 1977 Sep;155(4):594-8. PubMed PMID: 896809. 16: Kubacz GJ. The role of amino acids as stimulants of antral release. Aust N Z J Surg. 1974 May;44(2):186-92. PubMed PMID: 4533468. 17: Varga L, Fodor E, Sasvári M, Lonovics J, Varró V. BOC-14C-glycine pentapeptide metabolism in vitro in rat organ homogenates. Acta Med Acad Sci Hung. 1980;37(1):121-5. PubMed PMID: 7457014. 18: Varga L, Sasvári M, Penke B, Baláspiri L, Varró V. Metabolism of C-terminal pentapeptide of gastrin in the rat. Part III. The catabolism of the BOC-pentapeptide and its distribution in the organs. Acta Hepatogastroenterol (Stuttg). 1979 Dec;26(6):499-503. PubMed PMID: 549433. 19: Kato S, Takeuchi K, Okabe S. Mechanism by which histamine increases gastric mucosal blood flow in the rat. Role of luminal H+. Dig Dis Sci. 1993 Jul;38(7):1224-32. PubMed PMID: 8391973. 20: Varro V, Varga L, Chernai L, Nafradi I, Penke B. [Metabolism of the C-terminal pentapeptide of gastrin in the liver and mesentery of rats. Biliary secretion of labeled glycine pentapeptide]. Fiziol Zh SSSR Im I M Sechenova. 1973 Oct;59(10):1591-6. Russian. PubMed PMID: 4787871.