ARN70080 is a ProTAC building block. ARN70080 contains a von Hippel--Lindau (VHL)-rectuiting ligand and a pendant disulfide, linked via a carbonate group. The pendant disulfide allows for targeted degradation of antibodies. This product has no formal name at the moment. For the convenience of communication, a temporal code was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 121166
Name: ARN70080
CAS#: 2417370-08-0
Chemical Formula: C33H48N4O9S3
Exact Mass: 740.2583
Molecular Weight: 740.95
Elemental Analysis: C, 53.49; H, 6.53; N, 7.56; O, 19.43; S, 12.98
The following data is based on the product molecular weight 740.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
