Synonym
Dexketoprofen Free Base; UNII-6KD9E78X68; (S)-(+)-Ketoprofen
IUPAC/Chemical Name
Benzeneacetic acid, 3-benzoyl-alpha-methyl-, (S)-
InChi Key
DKYWVDODHFEZIM-NSHDSACASA-N
InChi Code
InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1
SMILES Code
O=C(O)[C@@H](C)C1=CC=CC(C(C2=CC=CC=C2)=O)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
254.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hanna M, Moon JY. A review of dexketoprofen trometamol in acute pain. Curr Med Res Opin. 2019 Feb;35(2):189-202. doi: 10.1080/03007995.2018.1457016. Epub 2018 Apr 24. PMID: 29569951.
2: Gaskell H, Derry S, Wiffen PJ, Moore RA. Single dose oral ketoprofen or dexketoprofen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2017 May 25;5(5):CD007355. doi: 10.1002/14651858.CD007355.pub3. PMID: 28540716; PMCID: PMC6481461.
3: Gay-Escoda C, Hanna M, Montero A, Dietrich T, Milleri S, Giergiel E, Zoltán TB, Varrassi G. Tramadol/dexketoprofen (TRAM/DKP) compared with tramadol/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study). BMJ Open. 2019 Feb 19;9(2):e023715. doi: 10.1136/bmjopen-2018-023715. Erratum in: BMJ Open. 2019 Jun 14;9(6):e023715corr1. PMID: 30782886; PMCID: PMC6377526.
4: What place is there for tramadol/dexketoprofen? Drug Ther Bull. 2018 Jun;56(6):66-68. doi: 10.1136/dtb.2018.6.0635. PMID: 29903752.
5: Taylan SB, Bariskaner H. Effects of dexmedetomidine and dexketoprofen on the conduction block of rat sciatic nerve. Neural Regen Res. 2020 May;15(5):929-935. doi: 10.4103/1673-5374.268926. PMID: 31719259; PMCID: PMC6990790.
6: Demirozogul E, Yilmaz A, Ozen M, Turkcuer I, Seyit M, Arikan C. Intravenous dexketoprofen versus paracetamol in non-traumatic musculoskeletal pain in the emergency department: A randomized clinical trial. Am J Emerg Med. 2019 Dec;37(12):2136-2142. doi: 10.1016/j.ajem.2019.01.040. Epub 2019 Feb 4. PMID: 30744914.
7: Barbanoj MJ, Antonijoan RM, Gich I. Clinical pharmacokinetics of dexketoprofen. Clin Pharmacokinet. 2001;40(4):245-62. doi: 10.2165/00003088-200140040-00002. PMID: 11368291.
8: Toledo MV, Briand LE. Relevance and bio-catalytic strategies for the kinetic resolution of ketoprofen towards dexketoprofen. Crit Rev Biotechnol. 2018 Aug;38(5):778-800. doi: 10.1080/07388551.2017.1399249. Epub 2017 Nov 10. PMID: 29124963.
9: Moore RA, Barden J. Systematic review of dexketoprofen in acute and chronic pain. BMC Clin Pharmacol. 2008 Oct 31;8:11. doi: 10.1186/1472-6904-8-11. PMID: 18976451; PMCID: PMC2585070.
10: Esparza-Villalpando V, Pozos-Guillén A, Masuoka-Ito D, Gaitán-Fonseca C, Chavarría-Bolaños D. Analgesic efficacy of preoperative dexketoprofen trometamol: A systematic review and meta-analysis. Drug Dev Res. 2018 Mar;79(2):47-57. doi: 10.1002/ddr.21419. Epub 2017 Dec 15. PMID: 29243848.
