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MedKoo Cat#: 414362 | Name: NGB 2904 Free Base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NGB 2904 Free Base is a dopamine D3 receptor antagonist.

Chemical Structure

NGB 2904 Free Base
CAS#189060-98-8 (free base)

Theoretical Analysis

MedKoo Cat#: 414362

Name: NGB 2904 Free Base

CAS#: 189060-98-8 (free base)

Chemical Formula: C28H29Cl2N3O

Exact Mass: 493.1688

Molecular Weight: 494.46

Elemental Analysis: C, 68.02; H, 5.91; Cl, 14.34; N, 8.50; O, 3.24

Price and Availability

Size Price Availability Quantity
10mg USD 369.00 2 Weeks
50mg USD 1,071.00 2 Weeks
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Related CAS #
189060-98-8 (free base) 189060-98-8 (HCl)
Synonym
NGB 2904 Free Base; NGB2904 Free Base; NGB-2904 Free Base
IUPAC/Chemical Name
9H-Fluorene-2-carboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-
InChi Key
YJPWVCIGSHWNON-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H29Cl2N3O/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24/h1-2,5-11,19H,3-4,12-18H2,(H,31,34)
SMILES Code
O=C(C1=CC(CC2=C3C=CC=C2)=C3C=C1)NCCCCN4CCN(C5=CC=CC(Cl)=C5Cl)CC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 494.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xi ZX, Gardner EL. Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction. CNS Drug Rev. 2007 Summer;13(2):240-59. doi: 10.1111/j.1527-3458.2007.00013.x. PMID: 17627675; PMCID: PMC3771110. 2: Xi ZX, Newman AH, Gilbert JG, Pak AC, Peng XQ, Ashby CR Jr, Gitajn L, Gardner EL. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology. 2006 Jul;31(7):1393-405. doi: 10.1038/sj.npp.1300912. Epub 2005 Oct 5. PMID: 16205781. 3: Yuan J, Chen X, Brodbeck R, Primus R, Braun J, Wasley JW, Thurkauf A. NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2715-8. doi: 10.1016/s0960-894x(98)00469-7. PMID: 9873609. 4: Banasikowski TJ, Beninger RJ. Reduced expression of haloperidol conditioned catalepsy in rats by the dopamine D3 receptor antagonists nafadotride and NGB 2904. Eur Neuropsychopharmacol. 2012 Oct;22(10):761-8. doi: 10.1016/j.euroneuro.2012.02.004. Epub 2012 Mar 10. PMID: 22410316. 5: Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR Jr, Heidbreder C, Gaál J, Gardner EL. The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats. Psychopharmacology (Berl). 2008 Mar;196(4):533-42. doi: 10.1007/s00213-007-0986-6. Epub 2007 Nov 6. PMID: 17985117; PMCID: PMC3713235. 6: Pritchard LM, Newman AH, McNamara RK, Logue AD, Taylor B, Welge JA, Xu M, Zhang J, Richtand NM. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol Biochem Behav. 2007 Apr;86(4):718-26. doi: 10.1016/j.pbb.2007.02.019. Epub 2007 Mar 6. PMID: 17408730. 7: Gilbert JG, Newman AH, Gardner EL, Ashby CR Jr, Heidbreder CA, Pak AC, Peng XQ, Xi ZX. Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors. Synapse. 2005 Jul;57(1):17-28. doi: 10.1002/syn.20152. PMID: 15858839; PMCID: PMC3726034. 8: Martelle JL, Claytor R, Ross JT, Reboussin BA, Newman AH, Nader MA. Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. J Pharmacol Exp Ther. 2007 May;321(2):573-82. doi: 10.1124/jpet.106.113571. Epub 2007 Feb 1. PMID: 17272677. 9: Thanos PK, Michaelides M, Ho CW, Wang GJ, Newman AH, Heidbreder CA, Ashby CR Jr, Gardner EL, Volkow ND. The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity. Pharmacol Biochem Behav. 2008 Jun;89(4):499-507. doi: 10.1016/j.pbb.2008.02.003. Epub 2008 Feb 8. PMID: 18329700; PMCID: PMC2681081. 10: Li S, Song JH, Kim TI, Yoo WG, Won MH, Dai F, Hong SJ. Chemotactic migration of newly excysted juvenile Clonorchis sinensis is suppressed by neuro- antagonists. PLoS Negl Trop Dis. 2019 Aug 13;13(8):e0007573. doi: 10.1371/journal.pntd.0007573. PMID: 31408466; PMCID: PMC6691982.

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