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MedKoo Cat#: 599198 | Name: Semduramicin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Semduramicin is a carboxylic acid ionophore for management of chicken coccidiosis.

Chemical Structure

Semduramicin
CAS#113378-31-7 (free acid)

Theoretical Analysis

MedKoo Cat#: 599198

Name: Semduramicin

CAS#: 113378-31-7 (free acid)

Chemical Formula: C45H76O16

Exact Mass: 872.5133

Molecular Weight: 873.08

Elemental Analysis: C, 61.91; H, 8.77; O, 29.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
119068-77-8 (sodium) 113378-31-7 (free acid)
Synonym
Semduramicin; UK 61,689; UK-61,689; UK61,689; Aviax;
IUPAC/Chemical Name
2-((2R,3S,4S,5R,6S)-2,4-dihydroxy-6-((R)-1-((2S,5S,7S,8R,9R)-9-hydroxy-2-((2R,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)-3'-(((2S,5S,6R)-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-methyloctahydro-[2,2'-bifuran]-5-yl)-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)ethyl)-5-methoxy-3-methyltetrahydro-2H-pyran-2-yl)acetic acid
InChi Key
WINSLRIENGBHSH-APGLQZKGSA-N
InChi Code
InChI=1S/C45H76O16/c1-22-18-23(2)43(9,50)58-36(22)30-19-31(55-34-13-12-29(52-10)27(6)54-34)40(56-30)42(8)15-14-32(57-42)41(7)16-17-44(61-41)20-28(46)24(3)37(59-44)25(4)38-39(53-11)35(49)26(5)45(51,60-38)21-33(47)48/h22-32,34-40,46,49-51H,12-21H2,1-11H3,(H,47,48)/t22-,23+,24+,25+,26-,27+,28+,29-,30+,31-,32+,34-,35-,36-,37-,38-,39+,40+,41-,42+,43-,44-,45+/m0/s1
SMILES Code
C[C@@H]1[C@@H](OC)CC[C@H](O[C@@H]2[C@H]([C@]3(C)O[C@@H]([C@@]4(CC[C@@]5(O4)O[C@@H]([C@@H]([C@@H](C5)O)C)[C@@H](C)[C@@H]6O[C@](O)(CC(O)=O)[C@@H](C)[C@H](O)[C@H]6OC)C)CC3)O[C@@H]([C@H]7O[C@@](O)(C)[C@H](C)C[C@@H]7C)C2)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 873.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Olejnik M, Szprengier-Juszkiewicz T, Jedziniak P. Distribution of semduramicin in hen eggs and tissues after administration of cross-contaminated feed. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(8):1393-8. doi: 10.1080/19440049.2014.927593. Epub 2014 Jun 18. PubMed PMID: 24856255. 2: Olejnik M, Szprengier-Juszkiewicz T, Jedziniak P. Semduramicin in eggs--the incompatibility of feed and food maximum levels. Food Chem. 2014 Apr 15;149:178-82. doi: 10.1016/j.foodchem.2013.10.091. Epub 2013 Nov 1. PubMed PMID: 24295692. 3: Vincent U, Serano F, de la Huebra MJ, von Holst C. Determination of semduramicin in poultry feed additive, premixture and compound feed by liquid chromatography and UV spectrophotometric detection after post-column derivatisation. J Pharm Biomed Anal. 2012 Mar 5;61:150-5. doi: 10.1016/j.jpba.2011.11.017. Epub 2011 Nov 22. PubMed PMID: 22169468. 4: Conway DP, Johnson JK, Guyonnet V, Long PL, Smothers CD. Efficacy of semduramicin and salinomycin against different stages of Eimeria tenella and E. acervulina in the chicken. Vet Parasitol. 1993 Jan;45(3-4):215-29. PubMed PMID: 8447065. 5: Logan NB, McKenzie ME, Conway DP, Chappel LR, Hammet NC. Anticoccidial efficacy of semduramicin. 2. Evaluation against field isolates including comparisons with salinomycin, maduramicin, and monensin in battery tests. Poult Sci. 1993 Nov;72(11):2058-63. PubMed PMID: 8265495. 6: Ricketts AP, Glazer EA, Migaki TT, Olson JA. Anticoccidial efficacy of semduramicin in battery studies with laboratory isolates of coccidia. Poult Sci. 1992 Jan;71(1):98-103. PubMed PMID: 1539028. 7: de la Huebra MJ, Vincent U, von Holst C. Determination of semduramicin in poultry feed at authorized level by liquid chromatography single quadrupole mass spectrometry. J Pharm Biomed Anal. 2010 Dec 1;53(4):860-8. doi: 10.1016/j.jpba.2010.06.011. Epub 2010 Jun 23. PubMed PMID: 20619995. 8: Watanabe H, Satake A, Kido Y, Tsuji A. [Development of monoclonal-based enzyme-linked immunosorbent assay and immunochromatographic assay for lasalocid and semduramicin]. Shokuhin Eiseigaku Zasshi. 2004 Jun;45(3):107-12. Japanese. PubMed PMID: 15468928. 9: González de la Huebra MJ, Vincent U, Serano F, von Holst C. Interlaboratory comparison of an analytical method for the determination of semduramicin in poultry feed at the authorized level using high-performance liquid chromatography coupled to postcolumn derivatization and spectrophotometric detection. J AOAC Int. 2012 Jan-Feb;95(1):61-6. PubMed PMID: 22468342. 10: Diniz GS, Borsoi A, Lopes JM, Garcia JL, Guimarães Junior Jda S. [Salinomycin and semduramicin in different concentrations on the broilers eimeriosis control]. Rev Bras Parasitol Vet. 2009 Oct-Dec;18(4):53-8. Portuguese. PubMed PMID: 20040210. 11: Pesti GM, Bakalli RI, Cervantes HM, Bafundo KW. Studies on semduramicin and nutritional responses: 2. methionine levels. Poult Sci. 1999 Aug;78(8):1170-6. PubMed PMID: 10472843. 12: McDougald LR, Mathis GF, Conway DP. Effect of semduramicin, salinomycin, and monensin on performance, shank pigmentation, and coccidial lesions in broiler chickens in floor pens. Avian Dis. 1996 Jan-Mar;40(1):68-71. PubMed PMID: 8713050. 13: Pesti GM, Bakalli RI, Cervantes HM, Bafundo KW. The influence of withdrawal time on the performance of broiler chickens fed semduramicin. Poult Sci. 2002 Jul;81(7):939-44. PubMed PMID: 12162353. 14: Schuhmacher A, Bafundo KW, Islam KM, Aupperle H, Glaser R, Schoon HA, Gropp JM. Tiamulin and semduramicin: effects of simultaneous administration on performance and health of growing broiler chickens. Poult Sci. 2006 Mar;85(3):441-5. PubMed PMID: 16553273. 15: Pesti GM, Bakalli RI, Cervantes HM, Bafundo KW. Studies on semduramicin and nutritional responses. 1. Level and source of protein. Poult Sci. 1999 Jan;78(1):102-6. PubMed PMID: 10023756. 16: Pesti GM, Cervantes H, Bakalli RI, Bafundo KW, Garcia MN. Studies on semduramicin and nutritional responses: 3. Electrolyte balance. Poult Sci. 1999 Nov;78(11):1552-60. PubMed PMID: 10560828. 17: Gonzalez de la Huebra MJ, Vincent U, von Holst C. Inter-laboratory comparison of an analytical method for the determination of the feed additive semduramicin in poultry feed at authorised level by liquid chromatography single quadrupole mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Jan;28(1):35-43. doi: 10.1080/19440049.2010.538727. PubMed PMID: 21240826. 18: Brake J, Cummings TS, Pinedo CR, Bafundo KW. Effects of the ionophore anticoccidial semduramicin on broiler breeders. Poult Sci. 2001 Mar;80(3):260-5. PubMed PMID: 11261553. 19: Ericson JF, Calcagni A, Lynch MJ. Determination of semduramicin sodium in poultry liver by liquid chromatography with vanillin postcolumn derivatization. J AOAC Int. 1994 May-Jun;77(3):577-82. PubMed PMID: 8012203. 20: Varga I, Jagicza A, Sréter T, Hornok S. Potentiation of ionophorous anticoccidials with dihydroquinolines: compatibility of lasalocid and semduramicin with duokvin. Int J Parasitol. 1995 Oct;25(10):1243-5. PubMed PMID: 8557471.