MedKoo Cat#: 535106 | Name: AL906

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AL906 is a novel and potent fluorescent EGFR inhibitor, selectively inhibiting the growth of the NIH3T3-EGFR and HER2 transfectants.

Chemical Structure

AL906
AL906
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 535106

Name: AL906

CAS#: N/A

Chemical Formula: C35H33ClN10O5

Exact Mass: 708.2324

Molecular Weight: 709.16

Elemental Analysis: C, 59.28; H, 4.69; Cl, 5.00; N, 19.75; O, 11.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AL906; AL-906; AL 906
IUPAC/Chemical Name
N-(4-((3-Chlorophenyl)amino)quinazolin-6-yl)-4-(2-((2-(N-methyl-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamido)ethyl)amino)ethyl)benzamide
InChi Key
OAXMELXHZSKWOL-UHFFFAOYSA-N
InChi Code
InChI=1S/C35H33ClN10O5/c1-45(31(47)14-16-38-29-11-12-30(46(49)50)33-32(29)43-51-44-33)18-17-37-15-13-22-5-7-23(8-6-22)35(48)42-26-9-10-28-27(20-26)34(40-21-39-28)41-25-4-2-3-24(36)19-25/h2-12,19-21,37-38H,13-18H2,1H3,(H,42,48)(H,39,40,41)
SMILES Code
O=C(NC1=CC2=C(NC3=CC=CC(Cl)=C3)N=CN=C2C=C1)C4=CC=C(CCNCCN(C)C(CCNC5=CC=C([N+]([O-])=O)C6=NON=C65)=O)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 709.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Golabi N, Larroque AL, Peyrard L, Williams C, Jean-Claude BJ. Subcellular distribution and mechanism of action of AL906, a novel and potent EGFR inhibitor rationally designed to be green fluorescent. Invest New Drugs. 2020 Jul 9. doi: 10.1007/s10637-020-00958-7. Epub ahead of print. PMID: 32648119.