Golcadomide (CC-99282) is a cereblon E3 ligase modulator (CELMoD) developed by Bristol Myers Squibb. It exhibits potent antitumor activity primarily through degradation of Ikaros (IKZF1) and Aiolos (IKZF3) transcription factors in B-cell malignancies. In preclinical studies, Golcadomide demonstrated sub-nanomolar DC₅₀ values for IKZF1 and IKZF3 in multiple myeloma and diffuse large B-cell lymphoma (DLBCL) cell lines, with DC₅₀ values typically in the range of 0.2–0.5 nM. It also induces apoptosis and inhibits proliferation in tumor cells by enhancing immune-stimulatory pathways.
MedKoo Cat#: 121077
Name: Golcadomide free base
CAS#: 2379572-34-4 (free base)
Chemical Formula: C28H30FN5O5
Exact Mass: 535.2231
Molecular Weight: 535.58
Elemental Analysis: C, 62.79; H, 5.65; F, 3.55; N, 13.08; O, 14.94
The following data is based on the product molecular weight 535.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
