Flumizole | CAS#36740-73-5 | NSAID

MedKoo Cat#: 525068 | Name: Flumizole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flumizole is an anti-inflammatory agent. It is a non-steroidal anti-inflammatory drug (NSAID) that acts via inhibition of the enzyme cyclooxygenase (COX).

Chemical Structure

Flumizole

CAS#36740-73-5

Theoretical Analysis

MedKoo Cat#: 525068

Name: Flumizole

CAS#: 36740-73-5

Chemical Formula: C18H15F3N2O2

Exact Mass: 348.1086

Molecular Weight: 348.32

Elemental Analysis: C, 62.07; H, 4.34; F, 16.36; N, 8.04; O, 9.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Flumizole; UNII-Y4YQF944N9; CP-22665; Flumizolum; Flumizol; Flumizole (USAN/INN); AC1L1XWB; Flumizol [INN-Spanish]; CP 22665. CP-22,665.

IUPAC/Chemical Name

4,5-Bis(p-methoxyphenyl)-2-(trifluoromethyl)imidazole

InChi Key

OPYFPDBMMYUPME-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23)

SMILES Code

c1(c(c2ccc(OC)cc2)nc([nH]1)C(F)(F)F)c1ccc(OC)cc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 348.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bender PE, Hill DT, Offen PH, Razgaitis K, Lavanchy P, Stringer OD, Sutton BM, Griswold DE, DiMartino M, Walz DT, et al. 5,6-Diaryl-2,3-dihydroimidazo[2,1-b]thiazoles: a new class of immunoregulatory antiinflammatory agents. J Med Chem. 1985 Sep;28(9):1169-77. PubMed PMID: 4032421. 2: Szczeklik A. Antipyretic analgesics and the allergic patient. Am J Med. 1983 Nov 14;75(5A):82-4. PubMed PMID: 6606363. 3: Kangasaho M, Vapaatalo H. TXA2-antagonistic properties of agents affecting prostaglandin synthesis or the cyclic nucleotide system in human platelets. Acta Pharmacol Toxicol (Copenh). 1983 Aug;53(2):130-4. PubMed PMID: 6624480. 4: McIlhenny HM, Levine S, Wiseman EH, Sowinski R. Disposition and activity in experimental allergic encephalomyelitis of flumizole, a nonacidic, nonsteroidal, anti-inflammatory agent. Exp Neurol. 1978 Jan 1;58(1):126-37. PubMed PMID: 618737. 5: Wiseman EH, McIlhenny HM, Bettis JW. Flumizole, a new nonsteroidal anti-inflammatory agent. J Pharm Sci. 1975 Sep;64(9):1469-75. PubMed PMID: 810570.