IUPAC/Chemical Name
2-cyclohexyl-4-isopropyl-N-((5-(tetrahydro-2H-pyran-2-yl)furan-2-yl)methyl)aniline; 2-Cyclohexyl-N-[[5-(oxan-2-yl)furan-2-yl]methyl]-4-propan-2-ylaniline
InChi Key
GYTVCHRGONLGMD-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H35NO2/c1-18(2)20-11-13-23(22(16-20)19-8-4-3-5-9-19)26-17-21-12-14-25(28-21)24-10-6-7-15-27-24/h11-14,16,18-19,24,26H,3-10,15,17H2,1-2H3
SMILES Code
CC(C)C(C=C1)=CC(C2CCCCC2)=C1NCC(O3)=CC=C3C4CCCCO4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
381.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nguyen TN, Nguyen BN, Lee JH, Panigrahi AK, Günzl A. Characterization of a novel class I transcription factor A (CITFA) subunit that is indispensable for transcription by the multifunctional RNA polymerase I of Trypanosoma brucei. Eukaryot Cell. 2012 Dec;11(12):1573-81. doi: 10.1128/EC.00250-12. Epub 2012 Oct 26. PMID: 23104567; PMCID: PMC3536272.
2: DeLeon C, Pemberton K, Green M, Kalajdzic V, Rosato M, Xu F, Arnatt C. Novel GPER Agonist, CITFA, Increases Neurite Growth in Rat Embryonic (E18) Hippocampal Neurons. ACS Chem Neurosci. 2022 Apr 20;13(8):1119-1128. doi: 10.1021/acschemneuro.1c00811. Epub 2022 Mar 30. PMID: 35353510.
3: Kirkham JK, Park SH, Nguyen TN, Lee JH, Günzl A. Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A. Mol Cell Biol. 2015 Oct 12;36(1):95-107. doi: 10.1128/MCB.00705-15. Erratum in: Mol Cell Biol. 2017 May 31;37(12 ): PMID: 26459761; PMCID: PMC4702606.
4: Nguyen TN, Müller LS, Park SH, Siegel TN, Günzl A. Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma brucei. Nucleic Acids Res. 2014 Mar;42(5):3164-76. doi: 10.1093/nar/gkt1301. Epub 2013 Dec 17. PMID: 24353315; PMCID: PMC3950698.
5: Kolev NG, Günzl A, Tschudi C. Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites. Mol Biochem Parasitol. 2017 Sep;216:52-55. doi: 10.1016/j.molbiopara.2017.07.002. Epub 2017 Jul 14. PMID: 28716719; PMCID: PMC5582990.
6: Park SH, Nguyen TN, Günzl A. Development of an efficient in vitro transcription system for bloodstream form Trypanosoma brucei reveals life cycle- independent functionality of class I transcription factor A. Mol Biochem Parasitol. 2012 Jan;181(1):29-36. doi: 10.1016/j.molbiopara.2011.09.009. Epub 2011 Sep 29. PMID: 21971062; PMCID: PMC3215803.
7: Park SH, Nguyen BN, Kirkham JK, Nguyen TN, Günzl A. A new strategy of RNA interference that targets heterologous sequences reveals CITFA1 as an essential component of class I transcription factor A in Trypanosoma brucei. Eukaryot Cell. 2014 Jun;13(6):785-95. doi: 10.1128/EC.00014-14. Epub 2014 Apr 11. PMID: 24728195; PMCID: PMC4054280.
