MedKoo Cat#: 565739 | Name: SMN-C2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SMN-C2 is a analog of rg-7916, acting as modulator of smn2 splicing, binding smn2 pre-mrna and thereby increasing the affinity of the rna binding proteins far upstream element binding protein 1 (fubp1) and kh-type splicing regulatory protein (khsrp) to the smn2 pre-mrna complex

Chemical Structure

SMN-C2
SMN-C2
CAS#1446311-56-3

Theoretical Analysis

MedKoo Cat#: 565739

Name: SMN-C2

CAS#: 1446311-56-3

Chemical Formula: C24H27N5O2

Exact Mass: 417.2165

Molecular Weight: 417.51

Elemental Analysis: C, 69.04; H, 6.52; N, 16.77; O, 7.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
SMN-C2; SMN C2; SMNC2
IUPAC/Chemical Name
(S)-3-(6,8-Dimethylimidazo[1,2-a]pyrazin-2-yl)-7-(4-ethyl-3-methylpiperazin-1-yl)-2H-chromen-2-one
InChi Key
PETSCYDXCUXNIW-INIZCTEOSA-N
InChi Code
InChI=1S/C24H27N5O2/c1-5-27-8-9-28(13-16(27)3)19-7-6-18-10-20(24(30)31-22(18)11-19)21-14-29-12-15(2)25-17(4)23(29)26-21/h6-7,10-12,14,16H,5,8-9,13H2,1-4H3/t16-/m0/s1
SMILES Code
O=C1C(C2=CN3C(C(C)=NC(C)=C3)=N2)=CC4=C(O1)C=C(N5C[C@H](C)N(CC)CC5)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 417.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang J, Schultz PG, Johnson KA. Mechanistic studies of a small-molecule modulator of SMN2 splicing. Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4604-E4612. doi: 10.1073/pnas.1800260115. Epub 2018 Apr 30. PubMed PMID: 29712837; PubMed Central PMCID: PMC5960314. 2: Wang J, Hammond J, Johnson KA. Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes. J Vis Exp. 2019 Jan 30;(143). doi: 10.3791/59021. PubMed PMID: 30774126.