BIBU-1361 is an EGFR inhibitor. BIBU1361 blocked epidermal growth factor-induced phosphorylation of EGFR and also prevented downstream responses such as mitogen-activated protein kinase kinase (MAPK/extracellular signal-regulated kinase kinase) and MAPK activation in cells. In accordance with these observations thymidine incorporation into EGFR-expressing KB cells was selectively and potently inhibited by BIBU1361 with half-maximally effective doses in the nanomolar range. Oral administration of BIBU-1361 inhibited the growth of established human xenografts in athymic mice, including vulval and head and neck squamous cell carcinomas.
MedKoo Cat#: 463991
Name: BIBU1361 free base
CAS#: 793726-84-8 (free base)
Chemical Formula: C22H27ClFN7
Exact Mass: 443.2000
Molecular Weight: 443.96
Elemental Analysis: C, 59.52; H, 6.13; Cl, 7.99; F, 4.28; N, 22.09
The following data is based on the product molecular weight 443.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
