SI-W052 is a novel anthranilate analogue (SI-W052) that inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α and interleukin (IL)-6 on microglia. To investigate its mechanism of action, herein, we postulate that SI-W052 exhibits anti-inflammatory activity through ER-stress-mediated autophagy.
MedKoo Cat#: 208243
Name: SI-W052
CAS#: unknown
Chemical Formula: C20H19ClN2O5S
Exact Mass: 434.0703
Molecular Weight: 434.90
Elemental Analysis: C, 55.24; H, 4.40; Cl, 8.15; N, 6.44; O, 18.39; S, 7.37
The following data is based on the product molecular weight 434.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
