SIAIS164018 is a protein degrader. SIAIS164018 could degrade not only ALK fusion proteins in activating or G1202R-mutated form but also mutant EGFR with L858R + T790M, which are two most important targets in non-small-cell lung cancer. SIAIS164018 strongly inhibited cell migration and invasion of Calu-1 and MDA-MB-231. Surprisingly, SIAIS164018 degrades several important oncoproteins involved in metastasis such as FAK, PYK2, and PTK6. Interestingly, SIAIS164018 reshuffled the kinome ranking profile when compared to Brigatinib. SIAIS164018 is orally bioavailable and well tolerated in vivo. SIAIS164018 is an enlightening degrader for us to excavate the charm of protein degradation.
MedKoo Cat#: 556111
Name: SIAIS164018
CAS#: 2353492-68-7
Chemical Formula: C43H48ClN10O7P
Exact Mass: 882.3134
Molecular Weight: 883.34
Elemental Analysis: C, 58.47; H, 5.48; Cl, 4.01; N, 15.86; O, 12.68; P, 3.51
The following data is based on the product molecular weight 883.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
