SHS4121705 is an efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitis. SHS4121705 displayed an EC50 of 4.3 μM in L6 myoblast cells and excellent oral bioavailability and liver exposure in mice. In the STAM mouse model of NASH, administration of 12i at 25 mg kg−1 day−1 lowered liver triglyceride levels and improved liver markers such as alanine aminotransferase, NAFLD activity score, and fibrosis.
MedKoo Cat#: 462065
Name: SHS4121705
CAS#: 2379550-82-8
Chemical Formula: C11H6F3N5O3
Exact Mass: 313.0423
Molecular Weight: 313.20
Elemental Analysis: C, 42.18; H, 1.93; F, 18.20; N, 22.36; O, 15.32
The following data is based on the product molecular weight 313.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
