BI-43 is a Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson’s Disease Mouse Model. In a MPTP-induced Parkinson’s disease (PD) mouse model, BI-43 manifested efficacy in mitigating locomotor deficits through reversing dopaminergic neuronal loss, reducing microglia, and decreasing levels of the sQC/ gQC substrates, α-synuclein, and CCL2.
MedKoo Cat#: 127119
Name: BI-43
CAS#: N/A
Chemical Formula: C27H23N5O3
Exact Mass: 465.1801
Molecular Weight: 465.51
Elemental Analysis: C, 69.66; H, 4.98; N, 15.04; O, 10.31
The following data is based on the product molecular weight 465.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
