WBC100 | CAS#2095780-08-6 | Degrader

MedKoo Cat#: 208234 | Name: WBC100

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WBC100 is a novel oral active molecule glue that selectively degrades c-Myc protein over other proteins and potently kills c-Myc overexpressing cancer cells is reported. WBC100 targets the nuclear localization signal 1 (NLS1)-Basic-nuclear localization signal 2 (NLS2) region of c-Myc and induces c-Myc protein degradation through ubiquitin E3 ligase CHIP mediated 26S proteasome pathway, leading to apoptosis of cancer cells.

Chemical Structure

WBC100

CAS#2095780-08-6

Theoretical Analysis

MedKoo Cat#: 208234

Name: WBC100

CAS#: 2095780-08-6

Chemical Formula: C25H33NO7

Exact Mass: 459.2257

Molecular Weight: 459.54

Elemental Analysis: Chemical Formula: C25H33NO7 Exact Mass: 459.2257 Molecular Weight: 459.5390 Elemental Analysis: C, 65.34; H, 7.24; N, 3.05; O, 24.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

WBC-100, WB-C100

IUPAC/Chemical Name

(5bS,6aS,7aR,8R,8aS,9aS,9bS,10aS,10bS)-8a-Isopropyl-10b-methyl-3-oxo-1,2,3,5,5b,6,6a,8,8a,9a,9b,10b-dodecahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-8-yl D-valinate

InChi Key

OWLJDBBFRJXPGM-VBIGTWTASA-N

InChi Code

InChI=1S/C25H33NO7/c1-10(2)16(26)20(28)30-21-23(11(3)4)17(32-23)18-25(33-18)22(5)7-6-12-13(9-29-19(12)27)14(22)8-15-24(21,25)31-15/h10-11,14-18,21H,6-9,26H2,1-5H3/t14-,15-,16+,17-,18-,21+,22-,23-,24+,25+/m0/s1

SMILES Code

C[C@]1(CC2)[C@@H](C[C@H](O3)[C@]43[C@@]1(O5)[C@@H]5[C@H](O6)[C@@]6(C(C)C)[C@H]4OC([C@H](N)C(C)C)=O)C7=C2C(OC7)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 459.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xu Y, Yu Q, Wang P, Wu Z, Zhang L, Wu S, Li M, Wu B, Li H, Zhuang H, Zhang X, Huang Y, Gan X, Xu R. A Selective Small-Molecule c-Myc Degrader Potently Regresses Lethal c-Myc Overexpressing Tumors. Adv Sci (Weinh). 2022 Mar;9(8):e2104344. doi: 10.1002/advs.202104344. Epub 2022 Jan 20. PMID: 35048559; PMCID: PMC8922104. 2: Pastore F, Pastore A, Wittmann G, Hiddemann W, Spiekermann K. The role of therapeutic leukapheresis in hyperleukocytotic AML. PLoS One. 2014 Apr 14;9(4):e95062. doi: 10.1371/journal.pone.0095062. PMID: 24733550; PMCID: PMC3986260. 3: Dumoulin EN, Van Biervliet S, De Vos M, Himpe J, Speeckaert MM, Delanghe JR. Faecal leukocyte esterase activity is an alternative biomarker in inflammatory bowel disease. Clin Chem Lab Med. 2015 Nov;53(12):2003-8. doi: 10.1515/cclm-2015-0040. PMID: 25883206. 4: Kuwae N, Kopple JD, Kalantar-Zadeh K. A low lymphocyte percentage is a predictor of mortality and hospitalization in hemodialysis patients. Clin Nephrol. 2005 Jan;63(1):22-34. doi: 10.5414/cnp63022. PMID: 15678693. 5: Wilkinson K, Fikes J, Wojcik S. Improved mouse blood smears using the DiffSpin slide spinner. Vet Clin Pathol. 2001;30(4):197-200. PMID: 12024302.