HYS-32 | CAS#1528729-98-7 | combretastatin A-4 analogue

MedKoo Cat#: 563077 | Name: HYS-32

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HYS-32 is an analogue of combretastatin A-4 that acts by enhancing connexin43 expression.

Chemical Structure

HYS-32

CAS#1528729-98-7

Theoretical Analysis

MedKoo Cat#: 563077

Name: HYS-32

CAS#: 1528729-98-7

Chemical Formula: C22H18O4

Exact Mass: 346.1205

Molecular Weight: 346.38

Elemental Analysis: C, 76.29; H, 5.24; O, 18.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HYS-32; HYS 32; HYS32;

IUPAC/Chemical Name

4-(3,4-Dimethoxyphenyl)-3-(naphthalen-2-yl)-2(5H)-furanone

InChi Key

JVWIHSGZUWAJAW-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H18O4/c1-24-19-10-9-16(12-20(19)25-2)18-13-26-22(23)21(18)17-8-7-14-5-3-4-6-15(14)11-17/h3-12H,13H2,1-2H3

SMILES Code

O=C1OCC(C2=CC=C(OC)C(OC)=C2)=C1C3=CC=C4C=CC=CC4=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 346.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chiu CT, Liao CK, Shen CC, Tang TK, Jow GM, Wang HS, Wu JC. HYS-32-Induced Microtubule Catastrophes in Rat Astrocytes Involves the PI3K-GSK3beta Signaling Pathway. PLoS One. 2015 May 4;10(5):e0126217. doi: 10.1371/journal.pone.0126217. eCollection 2015. PubMed PMID: 25938237; PubMed Central PMCID: PMC4418738. 2: Lin PC, Shen CC, Liao CK, Jow GM, Chiu CT, Chung TH, Wu JC. HYS-32, a novel analogue of combretastatin A-4, enhances connexin43 expression and gap junction intercellular communication in rat astrocytes. Neurochem Int. 2013 May;62(6):881-92. doi: 10.1016/j.neuint.2013.02.027. Epub 2013 Mar 14. PubMed PMID: 23500605.