SW43 is a synthetic ligand with high selectivity and affinity for the sigma-2 receptor (σ₂R), a receptor associated with cellular proliferation and implicated in cancer and neurodegenerative disease pathology. In binding assays, SW43 exhibits a Ki of approximately 13 nM for σ₂R, with significantly lower affinity for sigma-1 receptors (σ₁R), typically with a Ki >1 µM, demonstrating strong selectivity. Functional studies have shown that SW43 can induce cytotoxicity in various cancer cell lines, including pancreatic and breast cancer models, with IC₅₀ values in the low micromolar range (1–5 µM), suggesting potential for anti-tumor activity through σ₂R-mediated mechanisms, such as mitochondrial disruption, apoptosis, and autophagy induction.
MedKoo Cat#: 563110
Name: SW43 HCl
CAS#: SW43 HCl
Chemical Formula: C27H47Cl2N3O4
Exact Mass: 475.3410
Molecular Weight: 548.59
Elemental Analysis: C, 59.11; H, 8.64; Cl, 12.92; N, 7.66; O, 11.67
The following data is based on the product molecular weight 548.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
