Dacopafant | CAS# 125372-33-0 | SIRS antagonists

MedKoo Cat#: 581198 | Name: Dacopafant

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dacopafant is platlet activationg factor receptor (PAFR) antagonists. It had been in phase I clinical trials by Sanofi for the treatment of systemic inflammatory response syndrome and asthma. However, this research has been discontinued.

Chemical Structure

Dacopafant

CAS#125372-33-0

Theoretical Analysis

MedKoo Cat#: 581198

Name: Dacopafant

CAS#: 125372-33-0

Chemical Formula: C12H11N3OS

Exact Mass: 245.0623

Molecular Weight: 245.30

Elemental Analysis: C, 58.76; H, 4.52; N, 17.13; O, 6.52; S, 13.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Dacopafant; UNII-H1T03Z1G60;

IUPAC/Chemical Name

(3R)-3-(3-Pyridyl)-1H,3H-pyrrolo(1,2-c)thiazole-7-carboxamide

InChi Key

ARFOASMERCHFBY-GFCCVEGCSA-N

InChi Code

InChI=1S/C12H11N3OS/c13-11(16)9-3-5-15-10(9)7-17-12(15)8-2-1-4-14-6-8/h1-6,12H,7H2,(H2,13,16)/t12-/m1/s1

SMILES Code

O=C(C(C=C1)=C2N1[C@@H](C3=CC=CN=C3)SC2)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 245.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Serradji N, Bensaid O, Martin M, Kan E, Dereuddre-Bosquet N, Redeuilh C, Huet J, Heymans F, Lamouri A, Clayette P, Dong CZ, Dormont D, Godfroid JJ. Structure-activity relationships in platelet-activating factor (PAF). 10. From PAF antagonism to inhibition of HIV-1 replication. J Med Chem. 2000 Jun 1;43(11):2149-54. PubMed PMID: 10841793. 2: Clayette P, Dereuddre-Bosquet N, Martin M, Fretier P, Dormont D. Effects of RP 55778, a tumor necrosis factor alpha synthesis inhibitor, on antiviral activity of dideoxynucleosides. Antimicrob Agents Chemother. 1997 Apr;41(4):875-7. PubMed PMID: 9087512; PubMed Central PMCID: PMC163817. 3: Renesto P, Vicart P, Paulin D, Chignard M. Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils. Br J Pharmacol. 1996 Mar;117(5):902-6. PubMed PMID: 8851508; PubMed Central PMCID: PMC1909414. 4: van Rossem K, Vermariën H, Decuyper K, Bourgain R. The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. Adv Exp Med Biol. 1996;388:423-9. PubMed PMID: 8798843. 5: Koike H, Imanishi N, Natsume Y, Morooka S. Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils. Eur J Pharmacol. 1994 Nov 15;269(3):299-309. PubMed PMID: 7895770.