HBI2376 | SHP2 inhibitor

MedKoo Cat#: 128779 | Name: HBI2376

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HBI2376 is an allosteric SHP2 inhibitor.

Chemical Structure

HBI2376

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128779

Name: HBI2376

CAS#: N/A

Chemical Formula: C28H34ClN7O4S

Exact Mass: 599.2082

Molecular Weight: 600.14

Elemental Analysis: C, 56.04; H, 5.71; Cl, 5.91; N, 16.34; O, 10.66; S, 5.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HBI2376; HBI-2376; HBI 2376

IUPAC/Chemical Name

N-(3-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-2-hydroxy-4-oxo-3,4,6,7,8,9-hexahydro-2H-pyrido[1,2-a]pyrimidine-3-carboxamide

InChi Key

OWMGZWRBNVVPGL-CDBBXPDZSA-N

InChi Code

InChI=1S/C28H34ClN7O4S/c1-16-24(30)28(15-40-16)8-11-35(12-9-28)20-13-32-21(14-31-20)41-18-6-4-5-17(23(18)29)33-25(37)22-26(38)34-19-7-2-3-10-36(19)27(22)39/h4-6,13-14,16,22,24,26,38H,2-3,7-12,15,30H2,1H3,(H,33,37)/t16-,22?,24+,26?/m0/s1

SMILES Code

O=C1N2CCCCC2=NC(O)C1C(NC3=CC=CC(SC4=NC=C(N5CCC6([C@H](N)[C@H](C)OC6)CC5)N=C4)=C3Cl)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 600.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Wang M, Li T, Ouyang Z, Tang K, Zhu Y, Song C, Sun H, Yu B, Ji X, Sun Y. SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis. iScience. 2022 Mar 1;25(4):104009. doi: 10.1016/j.isci.2022.104009. PMID: 35310939; PMCID: PMC8927994. 2. Tang K, Zhao M, Wu YH, Wu Q, Wang S, Dong Y, Yu B, Song Y, Liu HM. Structure-based design, synthesis and biological evaluation of aminopyrazines as highly potent, selective, and cellularly active allosteric SHP2 inhibitors. Eur J Med Chem. 2022 Feb 15;230:114106. doi: 10.1016/j.ejmech.2022.114106. Epub 2022 Jan 12. PMID: 35063735.