CD33 Pre-mRNA Splicing Modulator 1 is one of the genetic variants in the CD33 gene that convey protection from late-onset Alzheimer's disease. Furthermore, mechanistic studies into GWAS-linked variants suggest that disease protection is attributed to the alternative splicing of exon 2 of the CD33 pre-mRNA. Using a phenomimetic screen, a series of compounds were found to enhance the exclusion of CD33 exon 2, acting as a chemomimetic of the GWAS-linked gene variants.
MedKoo Cat#: 208165
Name: CD33 Pre-mRNA Splicing Modulator 1
CAS#: unknown
Chemical Formula: C25H25FN6O
Exact Mass: 444.2074
Molecular Weight: 444.51
Elemental Analysis: C, 67.55; H, 5.67; F, 4.27; N, 18.91; O, 3.60
The following data is based on the product molecular weight 444.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
