MedKoo Cat#: 556212 | Name: NLRP3-IN-10
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NLRP3-IN-10 is a IL-1β inhibitor for the treatment of inflammation and inflammation-related disease (neurogenic inflammation, Alzheimer disease, etc.). This compound was reported in patent CN112745284.

Chemical Structure

NLRP3-IN-10
CAS#2641826-39-1

Theoretical Analysis

MedKoo Cat#: 556212

Name: NLRP3-IN-10

CAS#: 2641826-39-1

Chemical Formula: C17H14BrFO3

Exact Mass: 364.0110

Molecular Weight: 365.20

Elemental Analysis: C, 55.91; H, 3.86; Br, 21.88; F, 5.20; O, 13.14

Price and Availability

Size Price Availability Quantity
100mg USD 1,450.00 2 Weeks
1g USD 4,250.00 2 Weeks
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Related CAS #
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Synonym
NLRP3-IN-10; NLRP3 IN-10; NLRP3-IN 10; NLRP3 IN-10
IUPAC/Chemical Name
(E)-3-(4-bromo-2,5-dimethoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one
InChi Key
ZXMIFRJYIRYWTC-VMPITWQZSA-N
InChi Code
InChI=1S/C17H14BrFO3/c1-21-16-10-14(18)17(22-2)9-12(16)5-8-15(20)11-3-6-13(19)7-4-11/h3-10H,1-2H3/b8-5+
SMILES Code
BrC(C=C1OC)=C(C=C1/C=C/C(C2=CC=C(C=C2)F)=O)OC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 365.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Preparation of chalcone derivatives useful a IL-1β inhibitor for the treatment of inflammation By: Wu, Wenshuang; Zhang, Ruijia; Ye, Haoyu China, CN112745284 A 2021-05-04