Porfimer, also known as Photofrin, is a photosensitizing agent used in photodynamic therapy (PDT) for various cancers, including esophageal and non-small cell lung cancer. It is a mixture of oligomeric porphyrins that accumulate preferentially in tumor tissues. Upon activation by red light (~630 nm), porfimer generates singlet oxygen and reactive oxygen species, leading to direct tumor cell death and vascular damage. Clinically, a typical intravenous dose is 2 mg/kg, followed by light exposure 40–50 hours later. In a Phase III trial for early-stage lung cancer, porfimer PDT achieved complete response rates of 50–60% in obstructive endobronchial lesions, with tumor necrosis and minimal systemic toxicity beyond local photosensitivity lasting 30–90 days.
MedKoo Cat#: 100750
Name: Porfimer Sodium
CAS#: 87806-31-3 (sodium)
Chemical Formula:
Exact Mass:
Molecular Weight:
Elemental Analysis:
The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
