KSQ-4279, also known as RO7623066, is a USP1 and PARP inhibitor. KSQ-4279 showed anti-proliferative effects in a subset of cell lines, often characterized by the presence of homologous recombination deficiencies (HRD), including mutations in BRCA1/2. The combination of KSQ-4279 with olaparib was able to induce strong and durable regressions across a number of ovarian and TNBC PDX models.
MedKoo Cat#: 408175
Name: KSQ-4279
CAS#: 2446480-97-1
Chemical Formula: C27H25F3N8O
Exact Mass: 534.2103
Molecular Weight: 534.55
Elemental Analysis: C, 60.67; H, 4.71; F, 10.66; N, 20.96; O, 2.99
The following data is based on the product molecular weight 534.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
