Paederosidic Acid | CAS#18842-98-3 | Inhibitor

MedKoo Cat#: 112046 | Name: Paederosidic Acid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Paederosidic acid inhibits the proliferation of NCI H1650, HCC827, and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 40.68, 42.58, and 36.48 µg/ml, respectively). Paederosidic Acid suppressed osteoclast formation by downregulating expressions of NFAT2 and ATP6V0D2, as well as relieved neuropathic pain by decreasing expressions of CGRP, CSF1 and galanin in DRG.

Chemical Structure

Paederosidic Acid

CAS#18842-98-3

Theoretical Analysis

MedKoo Cat#: 112046

Name: Paederosidic Acid

CAS#: 18842-98-3

Chemical Formula: C18H24O12S

Exact Mass: 464.0988

Molecular Weight: 464.44

Elemental Analysis: C, 46.55; H, 5.21; O, 41.34; S, 6.90

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 410.00	2 Weeks
10mg	USD 750.00	2 Weeks

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Related CAS #

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Synonym

Paederosidic Acid

IUPAC/Chemical Name

(1S,4aS,5S,7aS)-5-hydroxy-7-((((methylthio)carbonyl)oxy)methyl)-1-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid

InChi Key

ICTKKPLVSHVNDV-FCVLBCLDSA-N

InChi Code

InChI=1S/C18H24O12S/c1-31-18(26)28-4-6-2-8(20)11-7(15(24)25)5-27-16(10(6)11)30-17-14(23)13(22)12(21)9(3-19)29-17/h2,5,8-14,16-17,19-23H,3-4H2,1H3,(H,24,25)/t8-,9+,10+,11-,12+,13-,14+,16-,17-/m0/s1

SMILES Code

OC(C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@]3([C@@]1([C@@H](O)C=C3COC(SC)=O)[H])[H])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	DMF	12.0	25.84
	DMSO	5.0	10.77
	Ethanol	12.0	25.84
	PBS (pH: 7.2)	5.0	10.77

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 464.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hu J, Yang GR, Ji R, Lv T, Li Q, Wang R. Cytotoxic iridoid glycosides from the leaves of Paederia scandens. J Asian Nat Prod Res. 2024 Jun 27:1-8. doi: 10.1080/10286020.2024.2358820. Epub ahead of print. PMID: 38934326. 2: Ai L, Guo L, Liu W, Xue X, Li L, Sheng Z, Gao C. Determination and Mechanism of Antidiarrheal Chemical Constituents of Paederia scandens Determined by HPLC-ESI-MS Integrated with Network Pharmacology. ACS Omega. 2023 Jul 24;8(31):28834-28845. doi: 10.1021/acsomega.3c03887. PMID: 37576641; PMCID: PMC10413830. 3: Li Y, Li Y, Zhu Y, Ji W, Wang Y, Dong X, Zhao X, Wang T, Tian S, Hu Q, Li H, Zhou M. Structure-based virtual screening for discovery of paederosidic acid from Paederia scandens as novel P2Y14R antagonist. Phytomedicine. 2023 Jul;115:154851. doi: 10.1016/j.phymed.2023.154851. Epub 2023 May 2. PMID: 37149963. 4: Yu P, Shi L, Song M, Meng Y. Antitumor activity of paederosidic acid in human non-small cell lung cancer cells via inducing mitochondria-mediated apoptosis. Chem Biol Interact. 2017 May 1;269:33-40. doi: 10.1016/j.cbi.2017.02.003. Epub 2017 Feb 7. PMID: 28185768. 5: Chen YF, Liu DH, Wu Q, Yang Y, Wang XW, Yang C, Zhang JY, Cai GJ. Possible mechanism involved in the antinociceptive activity of dimer of paederosidic acid and paederosidic acid methyl ester in mice. CNS Neurosci Ther. 2014 Feb;20(2):188-90. doi: 10.1111/cns.12215. Epub 2013 Dec 19. PMID: 24351037; PMCID: PMC6493019. 6: Hu HQ, Han HD, Lin Y, Chen LH, Wang XL. [Chemical constituents of Paederia pertomentosa]. Zhongguo Zhong Yao Za Zhi. 2013 Aug;38(16):2657-60. Chinese. PMID: 24228582. 7: Yang T, Kong B, Gu JW, Kuang YQ, Cheng L, Yang WT, Cheng JM, Ma Y, Yang XK. Anticonvulsant and sedative effects of paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats. Pharmacol Biochem Behav. 2013 Oct;111:97-101. doi: 10.1016/j.pbb.2013.08.015. Epub 2013 Sep 9. PMID: 24029464. 8: Jiang W, Jin D, Li Z, Sun Z, Chen M, Wu B, Huang C. Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction. Biomed Chromatogr. 2012 Jul;26(7):863-8. doi: 10.1002/bmc.1743. PMID: 22860258. 9: Ma Y, Zhou LL, Yan HY, Liu M. Effects of extracts from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on MSU crystal-induced rats gouty arthritis. Am J Chin Med. 2009;37(4):669-83. doi: 10.1142/S0192415X09007156. PMID: 19655406. 10: Chen YF, Huang Y, Tang WZ, Qin LP, Zheng HC. Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice. Pharmacol Biochem Behav. 2009 Aug;93(2):97-104. doi: 10.1016/j.pbb.2009.04.016. Epub 2009 May 3. PMID: 19409921. 11: Zou X, Liang J, Ding LS, Peng SL. [Studies on chemical constituents of Paederia scandense]. Zhongguo Zhong Yao Za Zhi. 2006 Sep;31(17):1436-41. Chinese. PMID: 17087085. 12: Ling SK, Tanaka T, Kouno I. Effects of iridoids on lipoxygenase and hyaluronidase activities and their activation by beta-glucosidase in the presence of amino acids. Biol Pharm Bull. 2003 Mar;26(3):352-6. doi: 10.1248/bpb.26.352. PMID: 12612446. 13: Quang DN, Hashimoto T, Tanaka M, Dung NX, Asakawa Y. Iridoid glucosides from roots of Vietnamese Paederia scandens. Phytochemistry. 2002 Jul;60(5):505-14. doi: 10.1016/s0031-9422(02)00096-1. PMID: 12052517. 14: Ling SK, Komorita A, Tanaka T, Fujioka T, Mihashi K, Kouno I. Sulfur- containing bis-iridoid glucosides and iridoid glucosides from Saprosmas cortechinii. J Nat Prod. 2002 May;65(5):656-60. doi: 10.1021/np010479o. PMID: 12027736.