HBX28364 | CAS#904444-86-6 | negative control for HBX19818

MedKoo Cat#: 130176 | Name: HBX28364

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HBX28364 is an inactive compound and serves as a negative control for HBX19818. The inactivity of the compound is a result of the lack of the basic alkyl amine side chain in HBX28364 as compared to HBX19818.

Chemical Structure

HBX28364

CAS#904444-86-6

Theoretical Analysis

MedKoo Cat#: 130176

Name: HBX28364

CAS#: 904444-86-6

Chemical Formula: C22H20Cl2N2O

Exact Mass: 398.0953

Molecular Weight: 399.32

Elemental Analysis: C, 66.17; H, 5.05; Cl, 17.76; N, 7.02; O, 4.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HBX28364; HBX-28364; HBX 28364; HBX 28,364; HBX28,364; HBX-28,364

IUPAC/Chemical Name

9-chloro-N-(4-chlorophenethyl)-5,6,7,8-tetrahydroacridine-3-carboxamide

InChi Key

XUIJWXHYLRBDEC-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H20Cl2N2O/c23-16-8-5-14(6-9-16)11-12-25-22(27)15-7-10-18-20(13-15)26-19-4-2-1-3-17(19)21(18)24/h5-10,13H,1-4,11-12H2,(H,25,27)

SMILES Code

O=C(C(C=CC1=C2Cl)=CC1=NC3=C2CCCC3)NCCC4=CC=C(Cl)C=C4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

HBX19818 is USP7 inhibitor for the exploration of the role of USP7 in endometrial stroma decidualization, a cause of failed pregnancies.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 399.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Reverdy C, Conrath S, Lopez R, Planquette C, Atmanene C, Collura V, Harpon J, Battaglia V, Vivat V, Sippl W, Colland F. Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme. Chem Biol. 2012 Apr 20;19(4):467-77. doi: 10.1016/j.chembiol.2012.02.007. PMID: 22520753. 2. Wu HQ, Baker D, Ovaa H. Small molecules that target the ubiquitin system. Biochem Soc Trans. 2020 Apr 29;48(2):479-497. doi: 10.1042/BST20190535. PMID: 32196552; PMCID: PMC7200645. 3. Cremer A, Stegmaier K. Targeting DUBs to degrade oncogenic proteins. Br J Cancer. 2020 Apr;122(8):1121-1123. doi: 10.1038/s41416-020-0728-7. Epub 2020 Feb 4. PMID: 32015509; PMCID: PMC7156467. 4. Gao Y, Wang Y, Zhou C, Kong S, Lu J, Wang H, Yang J. Ubiquitin-specific protease 7 (USP7) is essential for endometrial stromal cell decidualization in mice. Dev Growth Differ. 2019 Feb;61(2):176-185. doi: 10.1111/dgd.12594. Epub 2019 Jan 9. PMID: 30628051.