OICR766A | CAS#unknown | Bax activator

MedKoo Cat#: 464741 | Name: OICR766A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OICR766A is a novel Bax activator, having greatest effect enhancing the pro-apoptotic activity of Bax with EC50 values of ∼0.1 μM and ∼0.9 μM, respectively, inducing cell death by a Bax/Bak-dependent mechanism.

Chemical Structure

OICR766A

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464741

Name: OICR766A

CAS#: unknown

Chemical Formula: C25H26N4O

Exact Mass: 398.2107

Molecular Weight: 398.51

Elemental Analysis: C, 75.35; H, 6.58; N, 14.06; O, 4.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

OICR766A; OICR 766A; OICR-766A;

IUPAC/Chemical Name

3-((4-methylpiperazin-1-yl)(pyridin-2-yl)methyl)-2-phenyl-1H-indol-1-ol

InChi Key

KSPPFVMBFSONKS-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H26N4O/c1-27-15-17-28(18-16-27)25(21-12-7-8-14-26-21)23-20-11-5-6-13-22(20)29(30)24(23)19-9-3-2-4-10-19/h2-14,25,30H,15-18H2,1H3

SMILES Code

ON1C(C2=CC=CC=C2)=C(C(N3CCN(C)CC3)C4=NC=CC=C4)C5=C1C=CC=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 398.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brahmbhatt H, Uehling D, Al-Awar R, Leber B, Andrews D. Small molecules reveal an alternative mechanism of Bax activation. Biochem J. 2016 Apr 15;473(8):1073-83. doi: 10.1042/BCJ20160118. Epub 2016 Feb 25. PMID: 26916338; PMCID: PMC4847155.