KT109 is a selective inhibitor of DAGLβ with an IC50 value of 42 nM. DAGL-β (-/-) mice or KT109-treated wild-type mice displayed reductions in LPS-induced allodynia. Repeated KT109 administration prevented the expression of LPS-induced allodynia, without evidence of tolerance. Intraplantar injection of KT109 into the LPS-treated paw, but not the contralateral paw, reversed the allodynic responses. KT109 also reversed allodynia in the CCI and CINP models and lacked discernible side effects (e.g. gross motor deficits, anxiogenic behaviour or gastric ulcers).
MedKoo Cat#: 530444
Name: KT109
CAS#: 1402612-55-8
Chemical Formula: C27H26N4O
Exact Mass: 422.2107
Molecular Weight: 422.53
Elemental Analysis: C, 76.75; H, 6.20; N, 13.26; O, 3.79
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 10.0 | 23.67 | |
| DMSO | 10.0 | 23.67 |
The following data is based on the product molecular weight 422.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
