IDO1/2 Inhibitor 4t | CAS# | Inhibitor

MedKoo Cat#: 208045 | Name: IDO1/2 Inhibitor 4t

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IDO1/2 Inhibitor 4t is the first inhibitor targeting both IDO1/2 that has excellent in vitro inhibitory activity (IDO1 IC50 = 28 nM and IDO2 IC50 = 144 nM)

Chemical Structure

IDO1/2 Inhibitor 4t

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208045

Name: IDO1/2 Inhibitor 4t

CAS#: N/A

Chemical Formula: C16H18BrFN8O4

Exact Mass: 484.0618

Molecular Weight: 485.27

Elemental Analysis: C, 39.60; H, 3.74; Br, 16.47; F, 3.91; N, 23.09; O, 13.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IDO1/2 Inhibitor 4t; IDO1/2 Inhibitor4t; IDO1/2 Inhibitor-4t

IUPAC/Chemical Name

(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(4-((2-hydroxyethoxy)methyl)-1H-1,2,3-triazol-1-yl)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide

InChi Key

LFOXSTPPEXOYIT-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H18BrFN8O4/c17-12-7-10(1-2-13(12)18)20-16(22-28)14-15(24-30-23-14)19-3-4-26-8-11(21-25-26)9-29-6-5-27/h1-2,7-8,27-28H,3-6,9H2,(H,19,24)(H,20,22)

SMILES Code

OCCOCC1=CN(CCNC2=NON=C2/C(NC3=CC(Br)=C(F)C=C3)=N/O)N=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 485.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. He X, He G, Chu Z, Wu H, Wang J, Ge Y, Shen H, Zhang S, Shan J, Peng K, Wei Z, Zou Y, Xu Y, Zhu Q. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021 Dec 23;64(24):17950-17968. doi: 10.1021/acs.jmedchem.1c01305. Epub 2021 Dec 2. PMID: 34854662.