MedKoo Cat#: 464337 | Name: Isonanangenine B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.

Chemical Structure

Isonanangenine B
Isonanangenine B
CAS#1623153-14-9

Theoretical Analysis

MedKoo Cat#: 464337

Name: Isonanangenine B

CAS#: 1623153-14-9

Chemical Formula: C21H32O6

Exact Mass: 380.2199

Molecular Weight: 380.48

Elemental Analysis: C, 66.29; H, 8.48; O, 25.23

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Synonym
Isonanangenine B; Isonanangenine-B; SF002-96-1; SF002961; SF002 96 1;
IUPAC/Chemical Name
(5R,5aS,9R,9aR,9bS)-9,9b-dihydroxy-6,6,9a-trimethyl-3-oxo-1,3,5,5a,6,7,8,9,9a,9b-decahydronaphtho[1,2-c]furan-5-yl hexanoate
InChi Key
WQPFOWNSHXWLAY-NFWXSOHESA-N
InChi Code
InChI=1S/C21H32O6/c1-5-6-7-8-16(23)27-14-11-13-18(24)26-12-21(13,25)20(4)15(22)9-10-19(2,3)17(14)20/h11,14-15,17,22,25H,5-10,12H2,1-4H3/t14-,15-,17+,20+,21-/m1/s1
SMILES Code
CC1(CC[C@H]([C@]2([C@]1([C@@H](C=C3[C@@]2(COC3=O)O)OC(CCCCC)=O)[H])C)O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 380.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL