Kopsoffinol | CAS#96935-25-0 | bisindole alkaloid

MedKoo Cat#: 558581 | Name: Kopsoffinol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells.

Chemical Structure

Kopsoffinol

CAS#96935-25-0

Theoretical Analysis

MedKoo Cat#: 558581

Name: Kopsoffinol

CAS#: 96935-25-0

Chemical Formula: C40H48N4O3

Exact Mass: 632.3700

Molecular Weight: 632.85

Elemental Analysis: C, 75.92; H, 7.65; N, 8.85; O, 7.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Kopsoffinol; (+)-Kopsoffinol;

IUPAC/Chemical Name

O=C([C@@H]1[C@]2(CC3)NC4=C(C=C([C@@H]5N6C7=C(C8=C6C=CC=C8)CCN9[C@@]7([H])[C@@](CCC9)([C@H](O)C)C5)C=C4)[C@]2(CCN%10CCC%11)[C@]%10([H])[C@@]%113C1)OC

InChi Key

NKQJSTGACVZXMS-NXUBLSLISA-N

InChi Code

InChI=1S/C40H48N4O3/c1-24(45)38-13-6-17-42-19-11-27-26-7-3-4-8-31(26)44(33(27)34(38)42)32(23-38)25-9-10-30-28(21-25)39-16-20-43-18-5-12-37(36(39)43)14-15-40(39,41-30)29(22-37)35(46)47-2/h3-4,7-10,21,24,29,32,34,36,41,45H,5-6,11-20,22-23H2,1-2H3/t24-,29-,32-,34-,36+,37+,38-,39-,40+/m1/s1

SMILES Code

C1[C@@]23Nc4c([C@@]52[C@@H]2[C@@](CCC[N@@]2CC5)(C1)C[C@@H]3C(OC)=O)cc([C@@H]1n2c3[C@@H]5[C@@](C1)(CCC[N@@]5CCc3c1c2cccc1)[C@@H](C)O)cc4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 632.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yap WS, Gan CY, Sim KS, Lim SH, Low YY, Kam TS. Aspidofractinine and Eburnane 2. Alkaloids from a North Borneo Kopsia. Ring-Contracted, Additional Ring-Fused, and Paucidactine-Type Aspidofractinine Alkaloids from K. pauciflora. J Nat Prod. 2016 Jan 22;79(1):230-9. doi: 10.1021/acs.jnatprod.5b00992. Epub 2015 Dec 30. PubMed PMID: 26717050.