MedKoo Cat#: 466231 | Name: VH 032 amide-alkylC9-amine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VH 032 amide-alkylC9-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkyl C9 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Chemical Structure

VH 032 amide-alkylC9-amine
VH 032 amide-alkylC9-amine
CAS#2758364-04-2

Theoretical Analysis

MedKoo Cat#: 466231

Name: VH 032 amide-alkylC9-amine

CAS#: 2758364-04-2

Chemical Formula: C32H51Cl2N5O4S

Exact Mass: 671.3039

Molecular Weight: 672.75

Elemental Analysis: C, 57.13; H, 7.64; Cl, 10.54; N, 10.41; O, 9.51; S, 4.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
VH 032 amide-alkylC9-amine; VH 032 amide alkylC9-amine; VH 032 amide-alkylC9 amine; VH 032 amide alkylC9 amine;
IUPAC/Chemical Name
(2S,4R)-1-((S)-2-(10-aminodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
InChi Key
AGNKHPNSOVSYDF-HGIJPQKFSA-N
InChi Code
InChI=1S/C32H49N5O4S.2ClH/c1-22-28(42-21-35-22)24-15-13-23(14-16-24)19-34-30(40)26-18-25(38)20-37(26)31(41)29(32(2,3)4)36-27(39)12-10-8-6-5-7-9-11-17-33;;/h13-16,21,25-26,29,38H,5-12,17-20,33H2,1-4H3,(H,34,40)(H,36,39);2*1H/t25-,26+,29-;;/m1../s1
SMILES Code
CC(C)(C)[C@H](NC(CCCCCCCCCN)=O)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 672.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL