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MedKoo Cat#: 584763 | Name: Parsalmide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Parsalmide is anti-inflammatory analgesic with possible antianxiety action.

Chemical Structure

Parsalmide
Parsalmide
CAS#30653-83-9

Theoretical Analysis

MedKoo Cat#: 584763

Name: Parsalmide

CAS#: 30653-83-9

Chemical Formula: C14H18N2O2

Exact Mass: 246.1368

Molecular Weight: 246.31

Elemental Analysis: C, 68.27; H, 7.37; N, 11.37; O, 12.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Parsalmide; MY 41-6
IUPAC/Chemical Name
5-Amino-N-butyl-2-(2-propynyloxy)benzamide
InChi Key
DXHYQIJBUNRPJT-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H18N2O2/c1-3-5-8-16-14(17)12-10-11(15)6-7-13(12)18-9-4-2/h2,6-7,10H,3,5,8-9,15H2,1H3,(H,16,17)
SMILES Code
O=C(NCCCC)C1=CC(N)=CC=C1OCC#C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 246.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tafner G, Pedrazzoli M, Bajocchi E. [Controlled clinical trial of parsalmide, a drug with analgesic and anti-inflammatory activity]. Minerva Med. 1976 Oct 31;67(52):3383-90. Italian. PubMed PMID: 792737. 2: Menci S, Rossi M, Del Curatolo G, Orsucci PL. [Parsalmide, a new synthetic substance, in inflammatory and arthrosic arthropathies. Double-blind controlled clinical trial]. Minerva Med. 1976 Oct 31;67(52):3403-8. Italian. PubMed PMID: 792740. 3: Fantasia R, Colombi M, Della Volpe A, Pogliani EM. Inhibition of human platelet function by parsalmide. Arzneimittelforschung. 1982;32(10):1312-4. PubMed PMID: 6897511. 4: Fleischmann L, Pedrazzoli A. [In vitro studies on parsalmide / bioavailability and protein binding (author's transl)]. Arzneimittelforschung. 1977;27(6):1199-201. German. PubMed PMID: 20112. 5: Poli V. [Double-blind comparison of parsalmide and diazepam in anxious and depressive neurotic syndromes]. Minerva Med. 1976 Oct 31;67(52):3413-7. Italian. PubMed PMID: 11425. 6: Franchi R. [Controlled clinical trial of a new synthetic preparation (parsalmide) in the treatment of inflammatory and degenerative arthro-myopathies]. Minerva Med. 1976 Oct 31;67(52):3397-402. Italian. PubMed PMID: 792739. 7: Caliendo G, Santagada V, Perissutti E, Severino B, Fiorino F, Warner TD, Wallace JL, Ifa DR, Antunes E, Cirino G, de Nucci G. Synthesis of substituted benzamides as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 but do not cause gastric damage. Eur J Med Chem. 2001 Jun;36(6):517-30. PubMed PMID: 11525842. 8: Bianchetti A, Lavezzo A, Carminati P. The non-steroidal anti-inflammatory agent parsalmide prevents aspirin-induced H+ back diffusion from the gastric lumen of the rat. J Pharm Pharmacol. 1982 Jan;34(1):51-3. PubMed PMID: 6121035. 9: Cardoso HS, Bicalho B, Genari P, Santagada V, Caliendo G, Perissutti E, Donato JL, De Nucci G. In vitro mutagenicity of anti-inflammatory parsalmide analogues PA7, PA10, and PA31 triggered by biotransformation into hydroxy derivatives. Eur J Med Chem. 2006 Mar;41(3):408-16. Epub 2006 Jan 18. PubMed PMID: 16417948. 10: Bajardi A, Fantato S. [Controlled clinical trial of parsalmide]. Minerva Med. 1976 Oct 31;67(52):3371-5. Italian. PubMed PMID: 792735. 11: Mazue G, Berthe J, Richer G, Vallee E. Parsalmide: a new anti-inflammatory agent Note IX - Toxicological study of parsalmide; oral toxicity study in baboons. Boll Chim Farm. 1976 Feb;115(2):216-29. PubMed PMID: 820359. 12: Fleischmann L. [Metabolic aspects of parsalmide in the cat (author's transl)]. Arzneimittelforschung. 1980;30(2):294-8. German. PubMed PMID: 6892880. 13: Mirelli E, Fichera G, Boidi G. [Endoscopic study on the gastric tolerance of antalgic-antirheumatic substances:parsalmide]. Minerva Med. 1976 Oct 31;67(52):3361-70. Italian. PubMed PMID: 1086990. 14: Poli V. [Controlled clinical trial of parsalmide in patients with predominantly neuro-anxiety syndromes. Comparison with chlordiazepoxide]. Minerva Med. 1976 Oct 31;67(52):3409-12. Italian. PubMed PMID: 11424. 15: Bertaccini G, Molina E, Coruzzie G, Chiavarini M. [Effects of parsalmide on in vivo and in vitro gastric secretion]. Farmaco Prat. 1979 Nov;34(11):481-91. Italian. PubMed PMID: 583141. 16: Napoli A, Alderuccio B, Nannetti A. [Treatment of degenerative and inflammatory joint diseases with or without a new synthetic substance (parsalmide). Controlled clinical trial]. Clin Ter. 1977 Dec 15;83(5):541-7. Italian. PubMed PMID: 343972. 17: Maffi G, Dall'asta L, Pedrazzoli A. [Parsalmide: a new anti-inflammatory agent. II. Chemico-physical and analytical characteristics]. Boll Chim Farm. 1976 Feb;115(2):135-44. Italian. PubMed PMID: 949356. 18: Gruber C, Guzzon V, Ferrero E. [Parsalmide: a new anti-inflammatory agent. VII. Toxicological studies on tolerance in the rat]. Boll Chim Farm. 1976 Feb;115(2):195-208. Italian. PubMed PMID: 949361. 19: Ferrero E, Giudice A, Guzzon V, Pedrazzoli A. [Parsalmide: a new anti-inflammatory agent. III. Study of the analgesic and anti-inflammatory activity]. Boll Chim Farm. 1976 Feb;115(2):145-56. Italian. PubMed PMID: 949357. 20: Fleischmann L. [Pharmacokinetic and metabolic aspects of parsalmide in various animal species and man]. Boll Chim Farm. 1980 Jul;119(7):385-90. Italian. PubMed PMID: 6893933.

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