MedKoo Cat#: 464121 | Name: VH 032 amide-alkylC5-acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VH 032 amide-alkylC5-acid is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development. It incorporates an E3 ligase ligand plus alkylC5 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. It is part of a range of functionalized tool molecules for PROTAC R&D.

Chemical Structure

VH 032 amide-alkylC5-acid
VH 032 amide-alkylC5-acid
CAS#2162120-87-6

Theoretical Analysis

MedKoo Cat#: 464121

Name: VH 032 amide-alkylC5-acid

CAS#: 2162120-87-6

Chemical Formula: C29H40N4O6S

Exact Mass: 572.2669

Molecular Weight: 572.72

Elemental Analysis: C, 60.82; H, 7.04; N, 9.78; O, 16.76; S, 5.60

Price and Availability

Size Price Availability Quantity
25mg USD 550.00 2 Weeks
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Synonym
VH 032 amide-alkylC5-acid; VH 032 amide alkylC5-acid; VH 032 amide-alkylC5 acid; VH 032 amide alkylC5 acid;
IUPAC/Chemical Name
7-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptanoic acid
InChi Key
LYAMSRXTXVKKIC-TVZXLZGTSA-N
InChi Code
InChI=1S/C29H40N4O6S/c1-18-25(40-17-31-18)20-12-10-19(11-13-20)15-30-27(38)22-14-21(34)16-33(22)28(39)26(29(2,3)4)32-23(35)8-6-5-7-9-24(36)37/h10-13,17,21-22,26,34H,5-9,14-16H2,1-4H3,(H,30,38)(H,32,35)(H,36,37)/t21-,22+,26-/m1/s1
SMILES Code
CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCC(O)=O)=O)C(C)(C)C)=O)=O)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 572.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL