Synonym
Batebulast hydrochloride; Batebulast HCl; NCO 650; NCO650; NCO-650
IUPAC/Chemical Name
Cyclohexanecarboxylic acid, 4-(((aminoiminomethyl)amino)methyl)-, 4-(1,1-dimethylethyl)phenyl ester, monohydrochloride, trans-
InChi Key
RBXZATCLMSBPGG-SKKCDYJJSA-N
InChi Code
InChI=1S/C19H29N3O2.ClH/c1-19(2,3)15-8-10-16(11-9-15)24-17(23)14-6-4-13(5-7-14)12-22-18(20)21;/h8-11,13-14H,4-7,12H2,1-3H3,(H4,20,21,22);1H/t13-,14-;
SMILES Code
Cl.CC(C)(C)c1ccc(OC(=O)[C@@H]2CC[C@@H](CNC(=N)N)CC2)cc1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
367.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Misawa M, Takenouchi K, Sato M, Yanaura S. The effect of trans-4-guanidinomethylcyclohexanecarboxylic acid p-tert-butylphenyl ester hydrochloride (NCO-650) on Ascaris suum antigen-induced bronchoconstriction in dogs. Jpn J Pharmacol. 1987 Jan;43(1):53-60. doi: 10.1254/jjp.43.53. PMID: 2437348.
2: Akagi M, Mio M, Tasaka K. Histamine release inhibition and prevention of the decrease in membrane fluidity induced by certain anti-allergic drugs: analysis of the inhibitory mechanism of NCO-650. Agents Actions. 1983 Apr;13(2-3):149-56. doi: 10.1007/BF01967320. PMID: 6191546.
3: Nakayama S, Kawashima I, Kasahara T, Sakamoto K. Effects of p-tert- butylphenyl trans-4-guanidinomethylcyclohexane carboxylate hydrochloride (NCO-650) and its metabolite, p-tert-butylphenol(BP) on drug-metabolizing enzymes and fine structure in rat liver. J Toxicol Sci. 1988 May;13(2):71-81. doi: 10.2131/jts.13.71. PMID: 3172284.
4: Nakayama S, Kawashima I, Kasahara T, Sakamoto K. [Effect of p-tert- butylphenyl trans-4-guanidinomethyl cyclohexane carboxylate hydrochloride (NCO-650) on drug-metabolizing enzymes and fine structure in rat liver]. J Toxicol Sci. 1985 Aug;10(3):187-98. Japanese. doi: 10.2131/jts.10.187. PMID: 2866255.
5: Takei M, Matumoto T, Endo K, Muramatu M. Inhibitory effect of anti-allergic agent NCO-650 on histamine release induced by various secretagogues. Agents Actions. 1988 Aug;25(1-2):17-21. doi: 10.1007/BF01969088. PMID: 2461059.
6: Arakawa K, Tonooka M, Goto H, Sakamoto K. Membrane stabilizing action of NCO-650 and its congeners. Jpn J Pharmacol. 1984 Nov;36(3):311-8. doi: 10.1254/jjp.36.311. PMID: 6441049.
7: Misawa M, Takenouchi K, Sato M, Yanaura S. The effects of chlorpheniramine and antiallergic drugs on Ascaris suum antigen-induced active cutaneous anaphylaxis in dogs. Jpn J Pharmacol. 1987 May;44(1):101-4. doi: 10.1254/jjp.44.101. PMID: 2442443.
8: Misawa M, Takenouchi K, Shirakawa Y, Yanaura S. Effects of mast cell stabilizers on a new bronchial asthma model using compound 48/80 in dogs. Jpn J Pharmacol. 1987 Jun;44(2):197-205. doi: 10.1254/jjp.44.197. PMID: 2443734.
9: Takei M, Matumoto T, Endo K, Muramatu M. Inhibition of phospholipid methylation by an anti-allergic agent, NCO-650, during histamine release. Biochem Pharmacol. 1990 Oct 15;40(8):1773-8. doi: 10.1016/0006-2952(90)90355-o. PMID: 1978677.
10: Takei M, Matumoto T, Endo K, Muramatu M. Inhibition of cAMP increase by an anti-allergic agent, NCO-650, during histamine release. Int Arch Allergy Appl Immunol. 1989;88(4):377-80. doi: 10.1159/000234720. PMID: 2470687.
