SRI-37240 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. SRI-37240 showed improved potency and efficacy in FRT cells that translated to 16HBE14o- cells. RI-37240 induce a prolonged pause at stop codons and suppress PTCs associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function. SRI-37240 may be a promising treatment strategy for diseases caused by PTCs. Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination at PTCs.
MedKoo Cat#: 556076
Name: SRI-37240
CAS#: 883956-47-6
Chemical Formula: C24H23N3O2
Exact Mass: 385.1790
Molecular Weight: 385.47
Elemental Analysis: C, 74.78; H, 6.01; N, 10.90; O, 8.30
The following data is based on the product molecular weight 385.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
