IUPAC/Chemical Name
4(3H)-Quinazolinone, 2-((2,5-dimethoxyphenyl)methyl)-3-(2-(dimethylamino)ethyl)-6-(1-methylethoxy)-, monohydrochloride
InChi Key
WIEOHJFORIWYAS-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H31N3O4.ClH/c1-16(2)31-19-7-9-21-20(15-19)24(28)27(12-11-26(3)4)23(25-21)14-17-13-18(29-5)8-10-22(17)30-6;/h7-10,13,15-16H,11-12,14H2,1-6H3;1H
SMILES Code
O=C1N(CCN(C)C)C(CC2=CC(OC)=CC=C2OC)=NC3=C1C=C(OC(C)C)C=C3.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
461.99
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Ishibashi A, Horii D. Effect of MCI-176, a new calcium antagonist, on the calcium induced contraction of isolated porcine coronary arteries. Jpn J Pharmacol. 1987 Feb;43(2):234-6. PubMed PMID: 3573428.
3: Hosono M, Taira N. Coronary vasodilator versus cardiac effects of MCI-176, a novel quinazolinone calcium antagonist, in the dog heart. J Cardiovasc Pharmacol. 1987 Jun;9(6):633-40. PubMed PMID: 2442528.
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5: Ishibashi T, Nakazawa M, Imai S. Effect of MCI-176, a new calcium channel blocker, on large and small coronary arteries in dogs. Cardiovasc Res. 1989 Apr;23(4):295-302. PubMed PMID: 2590912.
6: Abe Y, Ichihara K, Abiko Y. Effects of MCI-176, a new quinazolinone calcium antagonist, on myocardial energy and carbohydrate metabolism in ischemic dog hearts. Biochem Pharmacol. 1991 Feb 1;41(3):445-51. PubMed PMID: 1825270.
7: Hara Y, Ichihara K, Abiko Y. MCl-176, a novel calcium channel blocker, attenuates the ischemic myocardial acidosis induced by coronary artery occlusion in dogs. J Pharmacol Exp Ther. 1988 Apr;245(1):305-10. PubMed PMID: 3361449.
8: Schleifer KJ, Tot E. Molecular modeling study of diltiazem mimics at L-type calcium channels. Pharm Res. 1999 Oct;16(10):1506-13. PubMed PMID: 10554090.
