ACP-105 | CAS# 899821-23-9 | SARM

MedKoo Cat#: 564693 | Name: ACP-105

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ACP-105 is a selective androgen receptor modulator (SARM).

Chemical Structure

ACP-105

CAS#899821-23-9

Theoretical Analysis

MedKoo Cat#: 564693

Name: ACP-105

CAS#: 899821-23-9

Chemical Formula: C16H19ClN2O

Exact Mass: 290.1186

Molecular Weight: 290.79

Elemental Analysis: C, 66.09; H, 6.59; Cl, 12.19; N, 9.63; O, 5.50

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
10mg	USD 600.00	2 Weeks
25mg	USD 1,250.00	2 Weeks

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Related CAS #

No Data

Synonym

ACP105; ACP 105; ACP-105

IUPAC/Chemical Name

2-Chloro-4-[(1R,5R)-3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octan-8-yl]-3-methylbenzonitrile

InChi Key

OUEODVPKPRQETQ-CHWSQXEVSA-N

InChi Code

InChI=1S/C16H19ClN2O/c1-10-14(6-3-11(9-18)15(10)17)19-12-4-5-13(19)8-16(2,20)7-12/h3,6,12-13,20H,4-5,7-8H2,1-2H3/t12-,13-/m1/s1

SMILES Code

N#CC1=CC=C(N2[C@@]3([H])CC(C)(O)C[C@@]2([H])CC3)C(C)=C1Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 290.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Subhahar MB, Karakka Kal AK, Philip M, K Karatt T, N I, Vazhat RA, M P MA. Detection and identification of ACP-105 and its metabolites in equine urine using LC/MS/MS after oral administration. Drug Test Anal. 2021 Feb;13(2):299-317. doi: 10.1002/dta.2918. Epub 2020 Sep 6. PMID: 32852865. 2: Thevis M, Schänzer W. Detection of SARMs in doping control analysis. Mol Cell Endocrinol. 2018 Mar 15;464:34-45. doi: 10.1016/j.mce.2017.01.040. Epub 2017 Jan 27. PMID: 28137616. 3: Dayger C, Villasana L, Pfankuch T, Davis M, Raber J. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice. Brain Res. 2011 Mar 24;1381:134-40. doi: 10.1016/j.brainres.2010.12.088. Epub 2011 Jan 8. PMID: 21219889; PMCID: PMC3048897. 4: Broberg MN, Knych H, Bondesson U, Pettersson C, Stanley S, Thevis M, Hedeland M. Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control. Metabolites. 2021 Feb 1;11(2):85. doi: 10.3390/metabo11020085. PMID: 33535528; PMCID: PMC7912737. 5: Brasileiro LS, Segabinazzi LGTM, Menezes E, Salgueiro CC, Novello G, Scheeren VFDC, Alvarenga MA, Nunes JF. Coconut Water as an Extender Component for Cooled Equine Sperm. J Equine Vet Sci. 2019 Jul;78:69-73. doi: 10.1016/j.jevs.2019.03.213. Epub 2019 Apr 17. PMID: 31203987. 6: Thevis M, Piper T, Beuck S, Geyer H, Schänzer W. Expanding sports drug testing assays: mass spectrometric characterization of the selective androgen receptor modulator drug candidates RAD140 and ACP-105. Rapid Commun Mass Spectrom. 2013 Jun 15;27(11):1173-82. doi: 10.1002/rcm.6558. PMID: 23650030. 7: Thevis M, Thomas A, Piper T, Krug O, Delahaut P, Schänzer W. Liquid chromatography-high resolution/ high accuracy (tandem) mass spectrometry-based identification of in vivo generated metabolites of the selective androgen receptor modulator ACP-105 for doping control purposes. Eur J Mass Spectrom (Chichester). 2014;20(1):73-83. doi: 10.1255/ejms.1236. PMID: 24881457. 8: Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P. Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes. Drug Test Anal. 2022 Feb;14(2):349-370. doi: 10.1002/dta.3189. Epub 2021 Dec 10. PMID: 34714606. 9: George S, Petit GH, Gouras GK, Brundin P, Olsson R. Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem Neurosci. 2013 Dec 18;4(12):1537-48. doi: 10.1021/cn400133s. Epub 2013 Sep 25. PMID: 24020966; PMCID: PMC3867967. 10: Schlienger N, Lund BW, Pawlas J, Badalassi F, Bertozzi F, Lewinsky R, Fejzic A, Thygesen MB, Tabatabaei A, Bradley SR, Gardell LR, Piu F, Olsson R. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators. J Med Chem. 2009 Nov 26;52(22):7186-91. doi: 10.1021/jm901149c. PMID: 19856921. 11: Gheddar L, Raul JS, Kintz P. Development and validation of SARMs and metabolic modulators screening in hair using UHPLC-MS/MS: Application to a doping case and first identification of S23 in authentic human hair. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Dec 15;1187:123048. doi: 10.1016/j.jchromb.2021.123048. Epub 2021 Nov 17. PMID: 34814052.