NNC63-0532 | CAS#250685-44-0

MedKoo Cat#: 525368 | Name: NNC63-0532

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NNC63-0532 is a potent and selective non-peptide agonist of the NOP receptors.

Chemical Structure

NNC63-0532

CAS#250685-44-0

Theoretical Analysis

MedKoo Cat#: 525368

Name: NNC63-0532

CAS#: 250685-44-0

Chemical Formula: C27H29N3O3

Exact Mass: 443.2209

Molecular Weight: 443.55

Elemental Analysis: C, 73.11; H, 6.59; N, 9.47; O, 10.82

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 415.00	2 Weeks
50mg	USD 1,415.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

NNC63-0532

IUPAC/Chemical Name

8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid, methyl ester

InChi Key

AQMPIDSGLFVVPL-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H29N3O3/c1-33-25(31)19-29-20-30(23-11-3-2-4-12-23)27(26(29)32)14-16-28(17-15-27)18-22-10-7-9-21-8-5-6-13-24(21)22/h2-13H,14-20H2,1H3

SMILES Code

O=C(OC)CN1CN(C2=CC=CC=C2)C3(CCN(CC4=C5C=CC=CC5=CC=C4)CC3)C1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NNC63-0532 is a potent and selective non-peptide agonist of the NOP receptors.

In vitro activity:

NNC 63-0532 showed only moderate affinity for the following receptors (K:(i) values in parentheses): mu-opioid (140 nM), kappa-opioid (405 nM), dopamine D(2S) (209 nM), dopamine D(3) (133 nM) and dopamine D(4.4) (107 nM) out of 75 different receptors, ion-channels and transporters. In functional assays, NNC 63-0532 was shown to be an agonist at ORL1 (EC(50)=305 nM), a much weaker agonist at the mu-opioid receptor (EC(50)>10 microM) and an antagonist or weak partial agonist at dopamine D(2S) (IC(50)=2830 nM). Reference: Br J Pharmacol. 2000 Nov;131(5):903-8. https://pubmed.ncbi.nlm.nih.gov/11053209/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	22.2	50.00
	Ethanol	2.2	5.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 443.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Thomsen C, Hohlweg R. (8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4. 5]dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist. Br J Pharmacol. 2000 Nov;131(5):903-8. doi: 10.1038/sj.bjp.0703661. PMID: 11053209; PMCID: PMC1572417.

In vitro protocol:

In vivo protocol:

TBD